COVID-19 and Hyper Inflammation Syndrome: Different Presentation and Management

COVID-19 as a viral infection is usually asymptomatic in children, but complications of this disease are not rare in children. Hyper inflammation of COVID-19 is a potentially fatal in undiagnosed children. It is very similar to Kawasaki disease, but with higher mortality and morbidity. Multi-organ involvement was reported in hyper inflammation syndrome following COVID-19. 

In this Research Topic, we will explore the management of hyper inflammation syndrome in children due to COVID- 19, and the obstacles pediatric physicians currently face. We welcome full research articles including original findings, review articles, systemic reviews, meta-analysis, and case reports, covering but not limited to, the following themes: 

·        Heterogeneity of manifestations of hyper inflammation syndrome in children

·        Cardiac involvement in hyper inflammation syndrome in children

·        Gastrointestinal and hepatobilary involvement in hyper inflammation syndrome in children

·        Kidney and urinary tract involvement in hyper inflammation syndrome in children

·        Respiratory system involvement in hyper inflammation syndrome in children

·        Central and peripheral nervous system involvement in hyper inflammation syndrome

·        Musculoskeletal manifestation of hyper inflammation syndrome in children

·        Hematologic manifestation of hyper inflammation syndrome in children

·        Dermatologic manifestation of hyper inflammation syndrome in children

·        Management of hyper inflammation syndrome in children under treatment with immunosuppressive treatment

·        The role of corticosteroid in management of hyper inflammation syndrome in children

·        The role of IVIg in management of hyper inflammation syndrome in children

·        The role of biologic drugs in management of hyper inflammation syndrome in children

·       Management of hyper inflammation syndrome in children with underlying disease such as rheumatologic disorders, malignancies, chronic respiratory disorders and primary immunodeficiency.