About this Research Topic
Cardiovascular disease [Major Adverse Cardiovascular Events [MACE], myocardial infarction, heart failure, cardiac dysrhythmias, stroke] remains the leading cause of death and major morbidity in industrialized countries. Concurrently it imposes a profound social and economic burden on society. Hypertension, cigarette use, diabetes mellitus, hyperlipidemia and male gender are established risk factors for subsequent development of cardiovascular disease. It is now also increasingly recognized however, that age progression per se: is also a risk factor for cardiovascular disease accrual; is incremental to and independent of traditional risk factors; and is characterized phenotypically by systolic hypertension with increased pulse pressure. The pathobiology underlying these age related vascular changes encompass interrelated functional and structural perturbations across all components of the vessel wall, intima/media/adventitia, and cellular/extracellular. The focus of this edition is to outline recent and emerging concepts underlying these vascular changes. Such an understanding could lead to the development of therapeutic strategies.
Cardiovascular remodeling, as a primary disease or as a consequence of pathologic changes secondary to aging or a primary disease, is a direct contributor to a shortened life span. The major goal of this proposal is to provide the reader with a compendium of cutting edge research topics that are directly linked to cardiovascular remodeling to gain a more complete understanding of the contributing factors and pathways that can be targeted to modify and treat cardiovascular remodeling. Recent advances have shown that stiffening of the vasculature is a systemic process affecting all vascular beds, encompasses changes of the whole vessel wall, and is directly linked to both structural cardiac remodeling, and impaired ventriculo-arterial coupling. Consequently, the proposed issue of Research Topics will broadly cover endothelial dysfunction, smooth muscle cell stiffness, extracellular remodeling of the heart and major vascular beds, as well as novel therapeutic approaches and advances in tissue engineering. The goal is to bring together a panel of experts comprising multiple specialties and fields of expertise. Moreover, this issue will identify novel targets and approaches that can be tested in clinical or pre-clinical models targeting cardiovascular remodeling in aging in disease.
This research topic will cover molecular, cellular, and physiological studies examining vascular and cardiac aging. Topics can range from biomechanics, matrix and cell-matrix communication, ventricular-vascular coupling, cardiac hypertrophy, and heart failure. Original research articles, brief communications, methods to study cardiovascular aging, and reviews are solicited.
Cardiovascular remodeling, as a primary disease or as a consequence of pathologic changes secondary to aging or a primary disease, is a direct contributor to a shortened life span. The major goal of this proposal is to provide the reader with a compendium of cutting edge research topics that are directly linked to cardiovascular remodeling to gain a more complete understanding of the contributing factors and pathways that can be targeted to modify and treat cardiovascular remodeling. Recent advances have shown that stiffening of the vasculature is a systemic process affecting all vascular beds, encompasses changes of the whole vessel wall, and is directly linked to both structural cardiac remodeling, and impaired ventriculo-arterial coupling. Consequently, the proposed issue of Research Topics will broadly cover endothelial dysfunction, smooth muscle cell stiffness, extracellular remodeling of the heart and major vascular beds, as well as novel therapeutic approaches and advances in tissue engineering. The goal is to bring together a panel of experts comprising multiple specialties and fields of expertise. Moreover, this issue will identify novel targets and approaches that can be tested in clinical or pre-clinical models targeting cardiovascular remodeling in aging in disease.
This research topic will cover molecular, cellular, and physiological studies examining vascular and cardiac aging. Topics can range from biomechanics, matrix and cell-matrix communication, ventricular-vascular coupling, cardiac hypertrophy, and heart failure. Original research articles, brief communications, methods to study cardiovascular aging, and reviews are solicited.
Keywords: Vascular matrix remodeling, vascular smooth muscle cell, vascular stiffness, endothelial dysfunction, ventricular-vascular coupling
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