About this Research Topic
Studies are needed to integrate emerging information on patient susceptibility and treatment with clinical risk factors for neurological complications. In this Research Topic, we try to identify novel interventions mitigating neurological complications among children undergoing cancer treatment. Multidisciplinary collaboration between primary care providers, pediatric oncologists, radiation oncologists and neuro-specialists is integral to the successful implementation of these interventions.
For this Research Topic, we would like to include Original Research and Review articles that focus on the pathophysiology, diagnosis, treatment, and outcomes of acute and long-term neurotoxicity in children treated for cancer. Topics will include both basic science and clinical research with a strong focus on, but not limited to, the following:
1. Emerging strategies in clinical management and prevention of neurological complications of cancer treatment
2. Impact of neurological complications on children with cancer.
3. Pathophysiology of neurological complications including paraneoplastic syndrome, encephalopathy, neuropathy, vasculopathy, neuro-endocrine dysfunction, and neurocognitive sequelae.
4. CNS infection management
5. Novel diagnostic approach and neuroimaging findings of neurological complications
6. Clinical trials targeting neuro-toxicity due to cancer therapy
Note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in Frontiers in Oncology.
Keywords: Children, Neurological sequelae, Chemotherapy, Radiation therapy, Cancer Treatment
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.