About this Research Topic
In order to translate these advancements into novel pharmacological strategies we need to 1) improve our understanding of the basic molecular mechanisms of chemotherapy resistance and biology of the disease, 2) identify novel therapeutic targets, 3) validate these targets into suitable pre-clinical models and 4) drive the development of novel pharmacological inhibitors or repositioning strategies. The Research Topic aims to boost the elucidation of KMT2A-R leukemia disease mechanisms and to facilitate the development of innovative therapies.
Areas to be covered in this Research Topic may include, but are not limited to:
o Development of novel mouse models of KMT2A-R leukemias
o Development of novel cell based models of KMT2A-R leukemias
o Identification of secondary mutations in KMT2A-R leukemias
o Progress in understanding the epigenetic landscape of KMT2A-R leukemias
o Role of Transcriptome aberrancies to KMT2A-R leukemias
o Novel therapeutic strategies
o Agents that increase sensitivity to standard chemotherapy
o Immunotherapy
o Contributing factors to chemotherapy resistance
Keywords: KMT2A, MLL, leukemia, therapy, epigenetics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.