Frontiers | The role of mitochondria, oxidative stress and altered calcium homeostasis in Amyotrophic Lateral Sclerosis: from current developments in the laboratory to clinical treatments.

The role of mitochondria, oxidative stress and altered calcium homeostasis in Amyotrophic Lateral Sclerosis: from current developments in the laboratory to clinical treatments.

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ORIGINAL RESEARCH

Published on 06 Jan 2017

Riluzole But Not Melatonin Ameliorates Acute Motor Neuron Degeneration and Moderately Inhibits SOD1-Mediated Excitotoxicity Induced Disrupted Mitochondrial Ca2+ Signaling in Amyotrophic Lateral Sclerosis

Manoj Kumar Jaiswal

doi 10.3389/fncel.2016.00295

7,569 views
31 citations

OPINION

Published on 23 Sep 2016

Promise and Pitfalls of Mitochondrial Replacement for Prevention and Cure of Heritable Neurodegenerative Diseases Caused by Deleterious Mutations in Mitochondrial DNA

Ananta Paine
Manoj Kumar Jaiswal

doi 10.3389/fncel.2016.00219

8,358 views
16 citations

ORIGINAL RESEARCH

Published on 09 May 2016

NSC-34 Motor Neuron-Like Cells Are Unsuitable as Experimental Model for Glutamate-Mediated Excitotoxicity

Blandine Madji Hounoum
Patrick Vourc’h
Romain Felix
Philippe Corcia
Franck Patin
Maxime Guéguinou
Marie Potier-Cartereau
Christophe Vandier
Cédric Raoul
2 more
Hélène Blasco

doi 10.3389/fncel.2016.00118

30,641 views
43 citations

ORIGINAL RESEARCH

Published on 22 Apr 2016

Gly482Ser PGC-1α Gene Polymorphism and Exercise-Related Oxidative Stress in Amyotrophic Lateral Sclerosis Patients

Angelique Pasquinelli
Lucia Chico
Livia Pasquali
Costanza Bisordi
Annalisa Lo Gerfo
Monica Fabbrini
Lucia Petrozzi
Letizia Marconi
Elena Caldarazzo Ienco
1 more
Gabriele Siciliano

doi 10.3389/fncel.2016.00102

4,124 views
18 citations

REVIEW

Published on 03 Mar 2016

Impaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron Degeneration

Brittany M. Edens
Nimrod Miller
Yong-Chao Ma

doi 10.3389/fncel.2016.00044

9,840 views
42 citations

REVIEW

Published on 29 Jan 2016

Adducin at the Neuromuscular Junction in Amyotrophic Lateral Sclerosis: Hanging on for Dear Life

Charles Krieger
Simon Ji Hau Wang
Soo Hyun Yoo
Nicholas Harden

doi 10.3389/fncel.2016.00011

5,258 views
11 citations

ORIGINAL RESEARCH

Published on 01 Dec 2015

Muscle Expression of SOD1G93A Modulates microRNA and mRNA Transcription Pattern Associated with the Myelination Process in the Spinal Cord of Transgenic Mice

Gabriella Dobrowolny
Camilla Bernardini
Martina Martini
Mirko Baranzini
Marta Barba
Antonio Musarò

doi 10.3389/fncel.2015.00463

4,461 views
26 citations

REVIEW

Published on 19 Nov 2015

ALS patient stem cells for unveiling disease signatures of motoneuron susceptibility: perspectives on the deadly mitochondria, ER stress and calcium triad

Anjoscha Kaus
Dhruv Sareen

doi 10.3389/fncel.2015.00448

14,029 views
34 citations

ORIGINAL RESEARCH

Published on 06 Nov 2015

Compartment-dependent mitochondrial alterations in experimental ALS, the effects of mitophagy and mitochondriogenesis

Gianfranco Natale
Paola Lenzi
Gloria Lazzeri
Alessandra Falleni
Francesca Biagioni
Larisa Ryskalin
Francesco Fornai

doi 10.3389/fncel.2015.00434

5,590 views
37 citations

ORIGINAL RESEARCH

Published on 06 Oct 2015

Homocysteine aggravates ROS-induced depression of transmitter release from motor nerve terminals: potential mechanism of peripheral impairment in motor neuron diseases associated with hyperhomocysteinemia

Ellya Bukharaeva
Anastasia Shakirzyanova
Venera Khuzakhmetova
Guzel Sitdikova
Rashid Giniatullin

doi 10.3389/fncel.2015.00391

4,836 views
29 citations

ORIGINAL RESEARCH

Published on 01 Sep 2015

Dysregulated expression of death, stress and mitochondrion related genes in the sciatic nerve of presymptomatic SOD1G93A mouse model of Amyotrophic Lateral Sclerosis

Chrystian Junqueira Alves
Jessica Ruivo Maximino
Gerson Chadi

doi 10.3389/fncel.2015.00332

5,708 views
9 citations

REVIEW

Published on 01 Sep 2015

Ultrastructural studies of ALS mitochondria connect altered function and permeability with defects of mitophagy and mitochondriogenesis

Riccardo Ruffoli
Alessia Bartalucci
Alessandro Frati
Francesco Fornai

doi 10.3389/fncel.2015.00341

6,286 views
35 citations

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Cellular Neurophysiology
Cellular Neuropathology
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Articles

Riluzole But Not Melatonin Ameliorates Acute Motor Neuron Degeneration and Moderately Inhibits SOD1-Mediated Excitotoxicity Induced Disrupted Mitochondrial Ca2+ Signaling in Amyotrophic Lateral Sclerosis

Promise and Pitfalls of Mitochondrial Replacement for Prevention and Cure of Heritable Neurodegenerative Diseases Caused by Deleterious Mutations in Mitochondrial DNA

NSC-34 Motor Neuron-Like Cells Are Unsuitable as Experimental Model for Glutamate-Mediated Excitotoxicity

Gly482Ser PGC-1α Gene Polymorphism and Exercise-Related Oxidative Stress in Amyotrophic Lateral Sclerosis Patients

Impaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron Degeneration

Adducin at the Neuromuscular Junction in Amyotrophic Lateral Sclerosis: Hanging on for Dear Life

Muscle Expression of SOD1G93A Modulates microRNA and mRNA Transcription Pattern Associated with the Myelination Process in the Spinal Cord of Transgenic Mice

ALS patient stem cells for unveiling disease signatures of motoneuron susceptibility: perspectives on the deadly mitochondria, ER stress and calcium triad

Compartment-dependent mitochondrial alterations in experimental ALS, the effects of mitophagy and mitochondriogenesis

Homocysteine aggravates ROS-induced depression of transmitter release from motor nerve terminals: potential mechanism of peripheral impairment in motor neuron diseases associated with hyperhomocysteinemia

Dysregulated expression of death, stress and mitochondrion related genes in the sciatic nerve of presymptomatic SOD1G93A mouse model of Amyotrophic Lateral Sclerosis

Ultrastructural studies of ALS mitochondria connect altered function and permeability with defects of mitophagy and mitochondriogenesis

Frontiers in Cellular Neuroscience

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