About this Research Topic
There are two types of AT: brown adipose tissue (BAT) and white adipose tissue (WAT). BAT dissipates glucose and fatty acid (FA) to generate heat, and thus it has an important role in cold- and diet-induced thermogenesis. WAT is the main organ responsible for fat storage.
TAG serves as the predominant form of lipid storage and is synthesized within the bilayer of endoplasmic reticulum (ER) membrane. The first step for TAG synthesis is converting glycerol 3-phosphate (G-3-P) and fatty acyl CoA (FA-CoA) to lysophosphatidate (LPA). TAG and other neutral lipids are then packaged into nascent LD which is budded from ER into the cytosol. After initial budding, newly formed LDs retain a functional connectivity with the ER, and keep expanding through fusion or local lipid synthesis. Under fasting, thermogenic or exercise conditions, TAG in LDs could be hydrolyzed by an enzymatic process called lipolysis to release FAs. FAs are taken up by BAT/muscle through membrane transporters and subsequently be utilized via β-oxidation within the mitochondria. The aim of this article collection is to promote our understanding of the whole processes of lipid metabolism within in the AT and skeletal muscle.
This Research Topic is intended to provide readers the basic research on the regulatory mechanisms of lipid metabolism in AT and skeletal muscle. We welcome Original research, Review, Mini-Review, Short communications and Perspectives articles that are related, but not limited to the following subtopics:
· White adipocyte, brown adipocyte and muscle cell differentiation.
· TAG synthesis in WAT.
· LD biogenesis and maintenance in WAT.
· Lipolysis in WAT and BAT.
· FA uptake by BAT and skeletal muscle.
· FA β-oxidation and mitochondria function in BAT and skeletal muscle.
· Dysregulated lipid metabolism in AT and skeletal muscle from any diseases.
· Potential therapeutic strategies to target lipid metabolism in AT and skeletal muscle.
Keywords: Lipid metabolism, adipose tissue, skeletal muscle, metabolic disorder
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