About this Research Topic
Pervasive transcription of the human genome produces a large set of RNA transcripts, which do not code for proteins, called non-coding RNA (ncRNA). There are a diverse class of ncRNAs known to regulate the post-transcriptional events, either by direct binding or through trans-acting mediators of mRNA transcripts. These ncRNA have emerged as one of the crucial players in maintaining the cellular homeostasis and are often found dysregulated in several human diseases including cancer, neurodegenerative diseases, developmental disorders, and cardiovascular disease.
The ncRNA are majorly classified as small ncRNA and long ncRNA based on their size. The regulation of gene expression by these ncRNA can target various post-transcriptional events like splicing, nuclear export, subcellular localization, translation, and stability of mRNA transcripts. Alteration in any of these post-transcriptional regulation events affect the cellular physiology and leads to human pathological conditions.
The objective of this Research Topic is to unravel the molecular intricacies and understanding the role of ncRNA in gene regulation at the post-transcriptional level in different human diseases. The submission of Original Research articles, Methods, Reviews, Mini Reviews, Perspectives and Opinions covering, but not limited to, the following topics are welcome:
• Role of small RNA (including microRNA, PIWI-interacting RNA, small nucleolar RNA etc.) in post-transcriptional regulation of gene expression in human diseases.
• Role of long ncRNA in post-transcriptional regulation of gene expression in human diseases.
• ncRNA as a therapeutic target in human diseases.
• Interaction of ncRNA with trans-acting factors like RNA binding proteins to regulate the gene expression in human diseases.
• Bioinformatic approaches to analyse RNA sequence data for the ncRNA (small and long ncRNA) expression in human diseases. In other words, multi-omic approaches to understand the complex interplay of ncRNA expression and gene expression.
The ncRNA are majorly classified as small ncRNA and long ncRNA based on their size. The regulation of gene expression by these ncRNA can target various post-transcriptional events like splicing, nuclear export, subcellular localization, translation, and stability of mRNA transcripts. Alteration in any of these post-transcriptional regulation events affect the cellular physiology and leads to human pathological conditions.
The objective of this Research Topic is to unravel the molecular intricacies and understanding the role of ncRNA in gene regulation at the post-transcriptional level in different human diseases. The submission of Original Research articles, Methods, Reviews, Mini Reviews, Perspectives and Opinions covering, but not limited to, the following topics are welcome:
• Role of small RNA (including microRNA, PIWI-interacting RNA, small nucleolar RNA etc.) in post-transcriptional regulation of gene expression in human diseases.
• Role of long ncRNA in post-transcriptional regulation of gene expression in human diseases.
• ncRNA as a therapeutic target in human diseases.
• Interaction of ncRNA with trans-acting factors like RNA binding proteins to regulate the gene expression in human diseases.
• Bioinformatic approaches to analyse RNA sequence data for the ncRNA (small and long ncRNA) expression in human diseases. In other words, multi-omic approaches to understand the complex interplay of ncRNA expression and gene expression.
Keywords: non-coding RNA, post-transcriptional regulation, gene expression, human disease, RNA
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