About this Research Topic
Sex hormones including estrogen, testosterone, progesterone, and the gonadotropin-follicle stimulating hormone, can regulate adipose tissue distribution, adipogenesis, and adipocyte metabolism and adipokine/cytokine production. Alternately, changes in adiposity and the cellular composition of adipose tissue regulate sex hormone production in both men and women, and adipocytes themselves contribute to circulating estrogen and testosterone levels. These cyclical and interrelated processes are especially evident at the menopausal transition, which is characterized by profound changes in sex hormone and gonadotropin production accompanied by the redistribution of fat from subcutaneous to abdominal visceral depots and pathologic changes in metabolic and inflammatory processes. Similar changes are observed with “adrenopause” in men, which is characterized by the slow loss of androgens from puberty to old age, and accompanied by a progressive increase in abdominal adiposity.
The complex reciprocal regulation of sex hormone production and adipose tissue composition and function provides a new framework for understanding normal sex hormone function and pathologies of gonadal aging. New gene targeting and pharmacologic strategies will be required to better understand how sex hormones modulate the cellular repertoire and distribution of adipose tissue, and explore hormone-induced changes in adipose tissue metabolism and inflammation. Single cell genomic and proteomic strategies will be valuable for obtaining a comprehensive picture of functional differences elicited by modulation of sex hormone levels, as well as provide a foundation for more detailed studies in human models. Substantial effort is currently directed at these and other strategies.
The aim of the current Research Topic is to explore promising recent and novel research trends in the field of Sex Hormones and Adipose Tissue Biology. Areas to be covered in this Research Topic may include, but are not limited to:
· Novel strategies to detect and quantify adipose tissue subpopulations.
· Single cell “-omics” strategies to functionally distinguish adipose tissue subpopulations, and measure sex hormone-induced changes on distinct cell populations.
· Identify specific adipose tissue populations in humans, and measure changes in cell abundance and phenotype in response to sex hormone/gonadotropin changes.
· Novel strategies to assess and manipulate the sex hormone environment in humans.
· Novel strategies to evaluate the impact of sex hormones/gonadotropins on brown and/or beige adipocytes.
· Novel strategies to measure sex hormone/gonadotropin-induced changes in metabolic and inflammatory endpoints that are regulated by adipose tissue.
· The role of sex hormones/gonadotropins in regulating the adipose tissue microenvironment and extracellular matrix.
This Research Topic welcomes Reviews, Mini Reviews, Original Research articles and Systematic Reviews.
Dr. Gavin is employed by Everly Health as of September 2021.
The complex reciprocal regulation of sex hormone production and adipose tissue composition and function provides a new framework for understanding normal sex hormone function and pathologies of gonadal aging. New gene targeting and pharmacologic strategies will be required to better understand how sex hormones modulate the cellular repertoire and distribution of adipose tissue, and explore hormone-induced changes in adipose tissue metabolism and inflammation. Single cell genomic and proteomic strategies will be valuable for obtaining a comprehensive picture of functional differences elicited by modulation of sex hormone levels, as well as provide a foundation for more detailed studies in human models. Substantial effort is currently directed at these and other strategies.
The aim of the current Research Topic is to explore promising recent and novel research trends in the field of Sex Hormones and Adipose Tissue Biology. Areas to be covered in this Research Topic may include, but are not limited to:
· Novel strategies to detect and quantify adipose tissue subpopulations.
· Single cell “-omics” strategies to functionally distinguish adipose tissue subpopulations, and measure sex hormone-induced changes on distinct cell populations.
· Identify specific adipose tissue populations in humans, and measure changes in cell abundance and phenotype in response to sex hormone/gonadotropin changes.
· Novel strategies to assess and manipulate the sex hormone environment in humans.
· Novel strategies to evaluate the impact of sex hormones/gonadotropins on brown and/or beige adipocytes.
· Novel strategies to measure sex hormone/gonadotropin-induced changes in metabolic and inflammatory endpoints that are regulated by adipose tissue.
· The role of sex hormones/gonadotropins in regulating the adipose tissue microenvironment and extracellular matrix.
This Research Topic welcomes Reviews, Mini Reviews, Original Research articles and Systematic Reviews.
Dr. Gavin is employed by Everly Health as of September 2021.
Keywords: adipose tissue, adipocyte, sex hormone, inflammation, metabolism
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
