About this Research Topic
The NF-κB family of dimeric transcription factors mediates critical biological functions in inflammation, innate immunity, cell proliferation and survival. In contrast, deregulation of NF-κB pathway components has been causally linked to the development of pathological processes including cancers, inflammatory and metabolic disorders. The complex roles of NF-κB in a multitude of cellular processes and diseases could be attributed to the hundreds of target genes whose expression are regulated by NF-κB factors involving transcriptional or epigenetic mechanisms. While previous investigations were mostly focused on the regulation of classical NF-κB pathway, there is increasing evidence for noncanonical NF-κB functions in inflammation and cancer. The microbiome also plays significant roles in regulating NF-κB signaling and abnormal perturbations in gut microbiota are associated with the incidence of diseases such as inflammatory bowel disease, Parkinson’s disease, type 2 diabetes mellitus and cancer, adding a new dimension to the biology of modern diseases. Although the aetiologies of these complex diseases are multifactorial, the involvement of several inflammatory loops are quite evident. NF-κB, being a key regulator in the crosstalk between multiple inflammatory pathways, serves as a matchmaker between inflammation and these modern diseases.
This Research Topic seeks to cover outstanding research illustrating recent developments in the regulatory roles of NF-κB factors in inflammation and cancer, as well as novel investigations which explore the tripartite link between microbiota, NF-κB and modern diseases.
Specific areas to be covered in this Research Topic may include the following:
1. NF-κB mediated transcriptional or epigenetic mechanisms in inflammation and cancer
2. Transcriptional specificity of NF-κB factors in inflammation and cancer
3. Role of NF-κB signaling in tumor-promoting inflammation
4. Regulation of NF-κB signaling by gut microbiota in health and disease
5. NF-κB signaling in stem cells and development, particularly cancer stem cells
6. Role of NF-κB associated long non-coding RNAs (lncRNAs) in inflammation and cancer progression
7. Role of noncanonical NF-κB signaling in inflammation and cancer
A full list of accepted article types, including descriptions, can be found at this link
This Research Topic seeks to cover outstanding research illustrating recent developments in the regulatory roles of NF-κB factors in inflammation and cancer, as well as novel investigations which explore the tripartite link between microbiota, NF-κB and modern diseases.
Specific areas to be covered in this Research Topic may include the following:
1. NF-κB mediated transcriptional or epigenetic mechanisms in inflammation and cancer
2. Transcriptional specificity of NF-κB factors in inflammation and cancer
3. Role of NF-κB signaling in tumor-promoting inflammation
4. Regulation of NF-κB signaling by gut microbiota in health and disease
5. NF-κB signaling in stem cells and development, particularly cancer stem cells
6. Role of NF-κB associated long non-coding RNAs (lncRNAs) in inflammation and cancer progression
7. Role of noncanonical NF-κB signaling in inflammation and cancer
A full list of accepted article types, including descriptions, can be found at this link
Keywords: NF-kB signaling, inflammation, cancer, microbiome
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