About this Research Topic
The main goal of this Research Topic (RT) is to improve the knowledge on the role of SPMs and their receptors in cardiometabolic, neurological and psychiatric disorders, gathering the scientific evidence on the pleiotropic effects elicited by these lipid mediators and shedding light on their therapeutic potential.
Original Research Articles, Brief Research Reports, Reviews or Mini-Reviews are types of manuscript of interest. The scope of this RT includes the fields of cardiometabolic, neurological and psychiatric disorders, addressing one or more of the following pathways elicited by SPMs:
- proresolving and anti-inflammatory mechanisms;
- modulation of oxidative stress;
- regulation of endothelial function;
- modulation of adaptive immunity;
- regulation of cell proliferation and migration;
- inhibition of angiotensin-converting enzyme (ACE)/angiotensin II (Ang II)/angiotensin II type 1 receptor (AT1R) axis/ stimulation of angiotensin converting enzyme 2 (ACE2)/angiotensin 1-7/Mas receptor axis;
- modulation of pain and neuroinflammation;
- neuromodulation (e.g. allosteric modulation; interference with neurotransmitter synthesis, release or degradation; synaptic plasticity).
Keywords: specialized proresolving mediators, pleiotropic effects, cardiometabolic diseases, neurological and psychiatric disorders, therapeutic potential
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.