About this Research Topic
In this Research Topic we focus on therapeutic approaches that target the reduction of α-synuclein inclusions in neurons and glial cells, as well as neuronal death induced by α-synuclein toxicity. Furthermore, an in-depth understanding why and how α-synuclein aggregates in the different cell types in PD and MSA develop is very important and should be covered in the current Research Topic, as it is also the basis for the development of new therapeutic approaches. Furthermore, for the correct diagnosis of PD and MSA and especially for the discrimination of these two diseases we are interested in diagnostic methods using α-synuclein as predictive marker.
Topic Editors welcome clinical or translational Research Articles, Reviews, Mini-Reviews, Perspectives or Opinions that cover, but are not limited to, the following topics:
• α-synuclein toxicity in PD and/or MSA
• aggregation properties of α-synuclein in neurons and/or glial cells
• α-synuclein aggregation initiation in PD and/or MSA
• α-synuclein as diagnostic, predictive marker for PD and MSA, and for the discrimination of PD and MSA (e.g. biomarker studies in blood, cerebrospinal fluid; MRI studies etc)
• therapeutic approaches targeting α-synuclein toxicity or aggregation properties
• immunogenicity of α-synuclein aggregates
Keywords: α-synuclein, multiple system atrophy (MSA), Parkinson’s disease (PD), Lewy bodies (LBs), glial cytoplasmic inclusions (GCIs)
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.