About this Research Topic
Biosynthesis of antimicrobial peptides (AMPs) has evolved as an evolutionarily ancient strategy to protect living organisms from pathogenic microbiota. Thus, a variety of AMPs exist that are highly efficient against the invading microbes. AMPs attract immense attention from the medical perspective as a potential alternative to the existing antimicrobials. In this regard, structure-and-function analysis of known and newly discovered AMPs is highly important as a framework supporting their potential applications as anti-infective agents.
In general, antimicrobials have a range of effects on target organisms, from regulatory to killing. In regard to AMPs, however, the effects of subinhibitory concentrations of AMPs on bacteria or fungi are poorly understood.
Thus, the aim of this Research Topic is to present a collection of research advances in the area that would expand our knowledge about various AMPs and their subinhibitory effects at the cellular and molecular level. We welcome all contributions made within the article types acceptable (more information found here):
This Research Topic is focused on, but not limited to, the following themes:
· What are the natural in situ concentrations of AMPs?
· Mutagenic effects of subinhibitory AMPs
· Effect of subinhibitory AMPs on microbial genome function
· Modulation of microbial virulence by subinhibitory AMPs
· Effect of subinhibitory AMPs on microorganisms at transcriptomic, proteomic and metabolomic levels
· Effect of subinhibitory AMPs on microorganisms at morphological, functional and population levels
· Emergence of resistance towards AMPs: cases and potential mechanisms
In general, antimicrobials have a range of effects on target organisms, from regulatory to killing. In regard to AMPs, however, the effects of subinhibitory concentrations of AMPs on bacteria or fungi are poorly understood.
Thus, the aim of this Research Topic is to present a collection of research advances in the area that would expand our knowledge about various AMPs and their subinhibitory effects at the cellular and molecular level. We welcome all contributions made within the article types acceptable (more information found here):
This Research Topic is focused on, but not limited to, the following themes:
· What are the natural in situ concentrations of AMPs?
· Mutagenic effects of subinhibitory AMPs
· Effect of subinhibitory AMPs on microbial genome function
· Modulation of microbial virulence by subinhibitory AMPs
· Effect of subinhibitory AMPs on microorganisms at transcriptomic, proteomic and metabolomic levels
· Effect of subinhibitory AMPs on microorganisms at morphological, functional and population levels
· Emergence of resistance towards AMPs: cases and potential mechanisms
Keywords: antimicrobial peptides, peptide antibiotics, subinhibitory effects, microbial virulence, antibiotic resistance
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
