About this Research Topic
In this research topic, we aim to showcase the current research highlighting the outcomes of cellular signaling modulation alongside low and high LET radiation in normal, radioresistant or hypoxic tumor cells. We welcome Original Research and Review articles reporting the radiobiological effects of low and high LET radiation (X-rays, gamma rays, and charged particles) both at the conventional and/or FLASH dose rates with or without cell-signaling pathways inhibitors for achieving better tumor control and normal tissue sparing. We also invite the views of the scientific community on the recent achievements in the development of radiation countermeasures as a result of modulating DNA damage and repair pathways.
Multidisciplinary articles spanning the Biological, Physical and Medical fields are welcome. Articles may report the radiobiological outcomes and mechanistic insights of modulating cellular signaling pathways in pre-clinical models of cancer and radioprotection. Articles combining experimental and modelling approaches to demonstrate therapeutic benefits, normal tissue sparing and relative biological effectiveness (RBE) of low and high LET radiation with or without molecular inhibitors are also welcome. Manuscripts from the medical field should report the clinical outcomes of combining DNA repair signaling inhibitors with X-rays, proton and other charged particles. Manuscripts reporting following outcomes are especially welcome:
1. Radiobiological effects of low and high LET radiations at conventional, FLASH and ultra-high dose rates.
2. Radiobiological outcomes of inhibiting cellular signaling pathways in pre-clinical cancer models of various origin by pharmaceutics.
3. Radiation mitigation and radioprotection achieved based on the modulation of DNA damage repair and other cell-signaling pathways.
4. Relative biological effectiveness (RBE) of low and high LET charged particles with or without cellular signaling inhibitors in achieving an enhanced therapeutic window or reducing normal tissue toxicity using various quality of radiations at variable dose rates.
5. Clinical outcomes of combining cell-signaling molecules or inhibitors with radiotherapy
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: radiotherapy, DNA repair inhibitors, FLASH radiotherapy, cellular signaling, DNA damage
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.