About this Research Topic
Various delayed mechanisms contribute to poor outcome after stroke occurrence. Inflammation, edema, and vascular dysfunction are just a few examples of pathophysiological events that are involved in the delayed injury process. Considerable research has been undertaken to understand these damaging processes, however, less is known about their respective contributions to delayed injury occurring 5-14 days after stroke. Furthermore, different stroke subtypes (i.e. ischemic vs hemorrhagic) have similar, yet slightly differing delayed injury mechanisms which can provide insight.
The goal of this Research Topic is to examine the delayed injury mechanisms after stroke. Most experimental research focuses on the acute injury phase following stroke. This includes looking at the roles that inflammation, edema, and vascular dysfunction play in the acute injury phase. However, research looking at the role of these events in the delayed phase (typically 3-10 days in animals, 5-14 days in humans) is limited, especially with respect to experimental studies. This collection will promote the importance of the delayed injury phase as a preventative treatment window, which can improve recovery from initial stroke (ischemic or hemorrhagic) injury. Furthermore, some stroke subtypes have sex differences in the response to delayed injury, which leads to significant differences in long-term outcome for males vs females. Recent research has begun showing the importance of delayed injury, including with respect to sex differences. Therefore, this Research Topic aims to promote further essential research studies in the field of delayed injury after ischemic and hemorrhagic stroke.
This collection will examine the various mechanisms involved in delayed injury following stroke. All stroke subtypes are acceptable. Areas of interest include, but are not limited to the following:
• Impact of delayed injury on stroke outcome, including consideration of sex differences
• Impact of acute injury on delayed injury mechanisms after stroke
• Role of secondary injuries on delayed injury and outcome after stroke
• Mechanisms as targets for therapy to prevent delayed injury after stroke
Only basic science papers are welcome. Original Research articles are preferred, however, any manuscript types will be considered.
Topic Editor, Dr. Devin McBride, received financial support from Celense. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
The goal of this Research Topic is to examine the delayed injury mechanisms after stroke. Most experimental research focuses on the acute injury phase following stroke. This includes looking at the roles that inflammation, edema, and vascular dysfunction play in the acute injury phase. However, research looking at the role of these events in the delayed phase (typically 3-10 days in animals, 5-14 days in humans) is limited, especially with respect to experimental studies. This collection will promote the importance of the delayed injury phase as a preventative treatment window, which can improve recovery from initial stroke (ischemic or hemorrhagic) injury. Furthermore, some stroke subtypes have sex differences in the response to delayed injury, which leads to significant differences in long-term outcome for males vs females. Recent research has begun showing the importance of delayed injury, including with respect to sex differences. Therefore, this Research Topic aims to promote further essential research studies in the field of delayed injury after ischemic and hemorrhagic stroke.
This collection will examine the various mechanisms involved in delayed injury following stroke. All stroke subtypes are acceptable. Areas of interest include, but are not limited to the following:
• Impact of delayed injury on stroke outcome, including consideration of sex differences
• Impact of acute injury on delayed injury mechanisms after stroke
• Role of secondary injuries on delayed injury and outcome after stroke
• Mechanisms as targets for therapy to prevent delayed injury after stroke
Only basic science papers are welcome. Original Research articles are preferred, however, any manuscript types will be considered.
Topic Editor, Dr. Devin McBride, received financial support from Celense. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Keywords: Delayed Injury, Delayed Deficits, Secondary Injury, Stroke, Brain Hemorrhage, Delayed Mechanisms
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
