About this Research Topic
The periodontal disease is an infection-driven, chronic inflammatory disease that results in the destruction of periodontal tissues, tooth loss and impaired dentition. It is of high incidence affecting millions of people worldwide. Its impact on the patient’s quality of life and on systemic health is linked with a plethora of other pathologies, ranging from diabetes to rheumatoid arthritis, making it a major public health problem.
The periodontal disease has a multifactorial etiology, making complex challenges of its pathogenesis, prevention and treatment. Indeed, if inflammation of the periodontal tissues is in response to the polymicrobial dysbiotic biofilms, it clearly links to the occurrence of the disease, genetic, epigenetic, environmental (smoking), mechanical, therapeutic (biotherapy, chemotherapy…) and endocrine factors as also implicated. The inflammation-induced alveolar bone destruction is the cardinal sign of the pathology that prefigures the tooth loss. Importantly, maintaining homeostasis of this “unique” bone from an embryological, structural and functional standpoint is of major therapeutic importance. Taking into account that osteolysis may also trigger and amplify the inflammation in the periodontium and inflammation present during coupled bone formation, this may limit the capacity to repair the resorbed bone.
The aim of the present Research Topic is to assemble manuscripts (original articles and reviews) addressing the questions relating to the alveolar bone physiopathology in the periodontal disease from the pathogenesis to the therapeutic approaches with no restriction regarding the field of the research: osteomicrobiology, osteoimmunology, inflammation, genetic, periodontal medicine, biomaterials, regeneration…
The periodontal disease has a multifactorial etiology, making complex challenges of its pathogenesis, prevention and treatment. Indeed, if inflammation of the periodontal tissues is in response to the polymicrobial dysbiotic biofilms, it clearly links to the occurrence of the disease, genetic, epigenetic, environmental (smoking), mechanical, therapeutic (biotherapy, chemotherapy…) and endocrine factors as also implicated. The inflammation-induced alveolar bone destruction is the cardinal sign of the pathology that prefigures the tooth loss. Importantly, maintaining homeostasis of this “unique” bone from an embryological, structural and functional standpoint is of major therapeutic importance. Taking into account that osteolysis may also trigger and amplify the inflammation in the periodontium and inflammation present during coupled bone formation, this may limit the capacity to repair the resorbed bone.
The aim of the present Research Topic is to assemble manuscripts (original articles and reviews) addressing the questions relating to the alveolar bone physiopathology in the periodontal disease from the pathogenesis to the therapeutic approaches with no restriction regarding the field of the research: osteomicrobiology, osteoimmunology, inflammation, genetic, periodontal medicine, biomaterials, regeneration…
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
