Inflammatory immune disease: Molecular Mechanisms, Translational Approaches and Therapeutics

Immunity is a physiological function of the human body. It maintains the health of the body by destroying and rejecting the "non-self" such as antigens, damaged cells and tumor cells produced by the body itself. Whether as a defense against foreign invasion or as an injury reaction, inflammation and immunity are closely related. During the past decades, inflammatory and immune disorders have become a growing health problem worldwide. Chronic systemic and regional inflammation underlies the disease manifestations of Immune-Mediated Inflammatory Diseases（IMIDs）. Regional inflammation and immune dysfunction promote targeted end-organ tissue damage, whereas systemic inflammation increases morbidity and mortality by affecting multiple organ systems. Chronic inflammation and skewed dysregulated cell-mediated immune responses drive many of these age-related medical disorders. IMIDs are commonly autoimmune-mediated or suspected to be autoimmune diseases. Another shared feature is dysregulation of the autonomic nervous system and hypothalamic pituitary adrenal (HPA) axis.

This Research Topic aims to investigate the pathogenesis and pathophysiological processes of inflammatory immune diseases (SLE, RA, psoriasis, atopic dermatitis), to explore the field of basic and clinical research, and to discover new therapeutic agents. From genetic data to basic function research of inflammatory immune diseases, potential new drug targets could be provided for inflammatory immune diseases by combining clinical case characteristics. Hence, this topic is intended to include research on screening new drugs from new targets, constructing susceptibility gene bank of patients with inflammatory and immune diseases, screening susceptible population, early diagnosis, pathological mechanism research, treatment target screening, drug development.

The purpose of this Research Topic is based on the genome-wide susceptibility gene search for inflammatory immune diseases, to explore the function of inflammatory immune diseases susceptibility genes, pathogenesis, target research, drug conversion and druggability research. In this Research Topic, we welcome original research articles, reviews, opinion, perspective, and systematic review, including but not limited to the following themes:

• Investigation on the pathophysiological mechanisms and new targets in inflammatory immune diseases
• Genome-wide susceptibility gene screening and the gene function research of inflammatory immune diseases
• Evaluation of drugs for the treatment and research into new drugs of inflammatory immune diseases
• Research on drug transformation and druggability of inflammatory immune diseases