About this Research Topic
The Research Topic is designed to allow some of these unanswered questions to be answered and discussed. The topics that we invite include:
• Receptor signaling mechanisms
• Pain processing events
• Cardiovascular roles
• Inflammatory and regulatory mechanisms
• Other, potentially new physiological roles of CGRP
• CGRP blockers and potential activities in different disease models
• Potential side effects and consequences of the long term use of antagonists and antibodies
• Comparison of different classes of CGRP blockers such as orally available small molecule CGRP antagonists and antibodies.
Overall this is a timely topic that will allow the wider understanding of CGRP biology, including and beyond migraine.
The Guest Editors encourage interested individuals or groups to submit an abstract before submitting their manuscript. Abstract submission deadline: 30 August 2021.
We would like to acknowledge Dr. Fulye Argunhan who contributed to the preparation of the proposal for this Research Topic.
Topic Editor Prof. Debbie Hay has received research funding from Alder, Living Cell Technologies, and acted as a consultant, speaker or advisor for Eli Lilly, Amgen, Teva, Merck, Intarcia Therapeutics. She has applied for patents on CGRP and amylin analogues. Topic Editor Prof. Andrew Russo has received research funding from Alder Biopharmaceuticals. He is a consultant for Lundbeck, Eli Lilly, Amgen, Novartis, Schedule One Therapeutics, Allergan, and Pharmnovo. He has patents on the CGRP enhancer and the use of CGRP-blocking antibodies to treat photophobia and diarrhea. A patent on the use of PACAP-blocking antibodies to treat photophobia is pending. Topic Editor Prof. Susan D Brain acted as a consultant for Eli Lilly and Syndermix.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.