About this Research Topic
Besides transplanting cells, there is increasing attention for the application of cardiac patches to restore cardiac function after injury, or the direct stimulation of endogenous cell types through e.g. small molecules or extracellular vesicles.
Our understanding of the cellular and molecular mechanisms that underlie repair in the injured heart has changed significantly over the last few years. The rise of novel techniques like single-cell sequencing provided insight into the cellular composition of the heart in healthy and diseased states. The possibility to perform small molecule screens resulted in the identification of compounds that for instance can induce cardiomyocyte proliferation or prevent fibrosis. Other studies have focused on the embryonic development or on regenerating species such as the zebrafish, to identify processes that may regulate cardiac repair. Finally, several off-the-shelf therapeutics like extracellular vesicles have shown great potential in stimulating many of the desired cell effects after damage. All these approaches have influenced our view on the endogenous repair capacity of the heart.
Reviews, short reviews and original data manuscripts are welcome covering:
1) Novel insights into cardiac cellular composition or cell behavior post-injury.
2) Advances in cardiac therapeutics including, but not limited to, extracellular vesicles, cardiac patches, cell transplantation, miRNA regulation and small molecule approaches.
3) Model systems that increase our understanding of cardiac repair processes.
The goal of this Research Topic is to highlight recent advances in cardiac repair and discuss their potential for future in vivo applications.
Keywords: cardiac repair, ischemic injury, myocardial infarction, regeneration, therapeutic approaches
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