Rational Immunogen Design for Next-Generation Antiviral Vaccines

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ORIGINAL RESEARCH

Published on 09 Dec 2021

A Stabilized, Monomeric, Receptor Binding Domain Elicits High-Titer Neutralizing Antibodies Against All SARS-CoV-2 Variants of Concern

Shahbaz Ahmed
Mohammad Suhail Khan
Savitha Gayathri
Randhir Singh
Sahil Kumar
Unnatiben Rajeshbhai Patel
Sameer Kumar Malladi
Raju S. Rajmani
Petrus Jansen van Vuren
17 more
Raghavan Varadarajan

A Stabilized, Monomeric, Receptor Binding Domain Elicits High-Titer Neutralizing Antibodies Against All SARS-CoV-2 Variants of Concern

doi 10.3389/fimmu.2021.765211

5,060 views
26 citations

MINI REVIEW

Published on 09 Dec 2021

Public Immunity: Evolutionary Spandrels for Pathway-Amplifying Protective Antibodies

Maya Sangesland
Daniel Lingwood

Public Immunity: Evolutionary Spandrels for Pathway-Amplifying Protective Antibodies

doi 10.3389/fimmu.2021.708882

1,516 views
4 citations

ORIGINAL RESEARCH

Published on 08 Dec 2021

Chimeric Fusion (F) and Attachment (G) Glycoprotein Antigen Delivery by mRNA as a Candidate Nipah Vaccine

Rebecca J. Loomis
Anthony T. DiPiazza
Samantha Falcone
Tracy J. Ruckwardt
Kaitlyn M. Morabito
Olubukola M. Abiona
Lauren A. Chang
Ria T. Caringal
Vladimir Presnyak
9 more
Barney S. Graham

Chimeric Fusion (F) and Attachment (G) Glycoprotein Antigen Delivery by mRNA as a Candidate Nipah Vaccine

doi 10.3389/fimmu.2021.772864

7,112 views
33 citations

ORIGINAL RESEARCH

Published on 07 Oct 2021

Altering the Immunogenicity of Hemagglutinin Immunogens by Hyperglycosylation and Disulfide Stabilization

Dana N. Thornlow
Andrew N. Macintyre
Thomas H. Oguin
Amelia B. Karlsson
Erica L. Stover
Heather E. Lynch
Gregory D. Sempowski
Aaron G. Schmidt

Altering the Immunogenicity of Hemagglutinin Immunogens by Hyperglycosylation and Disulfide Stabilization

doi 10.3389/fimmu.2021.737973

4,009 views
15 citations

ORIGINAL RESEARCH

Published on 26 Jul 2021

Structural Basis for SARS-CoV-2 Nucleocapsid Protein Recognition by Single-Domain Antibodies

Qiaozhen Ye
Shan Lu
Kevin D. Corbett

Structural Basis for SARS-CoV-2 Nucleocapsid Protein Recognition by Single-Domain Antibodies

doi 10.3389/fimmu.2021.719037

14,284 views
46 citations

ORIGINAL RESEARCH

Published on 29 Jun 2021

Stabilization of the SARS-CoV-2 Spike Receptor-Binding Domain Using Deep Mutational Scanning and Structure-Based Design

Daniel Ellis
Natalie Brunette
Katharine H. D. Crawford
Alexandra C. Walls
Minh N. Pham
Chengbo Chen
Karla-Luise Herpoldt
Brooke Fiala
Michael Murphy
17 more
Neil P. King

Stabilization of the SARS-CoV-2 Spike Receptor-Binding Domain Using Deep Mutational Scanning and Structure-Based Design

doi 10.3389/fimmu.2021.710263

10,971 views
45 citations

ORIGINAL RESEARCH

Published on 22 Apr 2021

Enhancing the Prefusion Conformational Stability of SARS-CoV-2 Spike Protein Through Structure-Guided Design

Timothy P. Riley
Hui-Ting Chou
Ruozhen Hu
Krzysztof P. Bzymek
Ana R. Correia
Alexander C. Partin
Danqing Li
Danyang Gong
Zhulun Wang
2 more
Fernando Garces

Enhancing the Prefusion Conformational Stability of SARS-CoV-2 Spike Protein Through Structure-Guided Design

doi 10.3389/fimmu.2021.660198

15,729 views
38 citations

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Frontiers in Immunology

Vaccines and Molecular Therapeutics

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Frontiers in Public Health
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