About this Research Topic

Background

In line with the understanding of muscle-tendon unit at the molecular and cellular level, research is being developed in areas inherent to tendinous remodeling and extracellular matrix adapting to load mechanisms (resistance training), androgenic anabolic steroids, aging, tendon lesion, and other studies associating extracellular matrix (ECM) remodeling in skeletal muscle as well. However, we are interested in developing and overcoming new challenges, which involve specifically tendon, cartilage, and bone.

The overall aim of this Research Topic is to investigate how the muscle-tendon unit adapts under mechanical unloading and loading conditions, lesion, and aging as well related to basic science. Another goal is to characterize the role of the extracellular matrix, the matrix cell interactions with molecular pathways, and the morphological tissue properties in these conditions. The research outcomes will drive new insights into physical activity-related problems, inactivity, aging and other factors that affect both muscle and tendon. We intend to set up multidisciplinary and integrative research under the scope of physiology and molecular-cellular biology regarding the muscle-tendon unit. To endorse the merging, expansion, and internationalization of science and technology, innovation including tissue engineering in this field is also a goal in the Research Topic.

• Molecular and cellular pathways in response of tendon and skeletal muscle injury
• Chronic and acute molecular and cellular responses in loading, unloading and aging
• ECM remodelling in response to tendon and skeletal muscle injury, mechanical loading and unloading
• Molecular mechanisms leading to tendinopathy
• Connective tissue in muscle and tendons tissue and cells interaction
• How the muscle-tendon unit adapts to inactivity and immobilization in combination with injury and aging.

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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