About this Research Topic
Recent advances in the development of human 3D in vitro tissue models provide a necessary tool for overcoming the above-mentioned limitations of infection models. Organoids, bioengineered 3D tissues and organ-on-chip technology can all find an application not only in regenerative medicine, toxicology or tumor biology, but could advance our understanding of infection, as well.
In this Research Topic, the focus would not be only on development, improvement and adaptation of available 3D tissue models based on human and/or mouse cells, which include organoids, bioengineered 3D tissues and organ-on-chip technology, but also on their application in infection research. The Research Topic would bring into spotlight recent experimental advances in the generation of 3D models for the purpose of studying the interaction of pathogenic microorganisms with the host, as well as new techniques that enable evaluation and analysis of this interaction. The latter would include microscopy, such as super-resolution microscopy, single cell and dual RNA-Seq, gene silencing in primary cells, etc. Our aim is to highlight studies that lead to understanding of the important events in infection using 3D tissue models, also including modelling of resulting pathologies, such as infection-associated cancers and the aspect of the development of new preventive and therapeutic strategies. The submission of both Original Research and Review articles would be welcomed.
Keywords: 3D models, organoids, pathogen-host interaction, biofabrication, infection
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