Transcriptional Regulation in Metabolism and Immunology

The regulation of transcription, the conversion of DNA to RNA, is a vital process in all living organisms to orchestrate gene activity. Transcription factors (TFs) are the important factors to orchestrate transcription by binding to specific DNA sequences to activate and/or repress wide repertoires of downstream target genes that control a wide variety of biological processes, including metabolic and immune systems. A large number of TFs that play critical roles in regulating transcription in the metabolic and immune systems have been investigated and much has been learned about their mechanisms. With the progress of high throughput sequencing and other state-of-the-art technologies, some recent studies have precisely highlighted dysregulated TFs in specific contexts. However, the field still remains in its infancy, with the complexity of gene regulation circuitry limiting our current knowledge and providing formidable barriers to further advancement.

This Research Topic is dedicated to publishing studies revealing the mechanisms of transcriptional regulation in metabolic and/or immune systems based on the data sets from next-generation sequencing and other state-of-the-art technologies, which will shed light on the deeper understanding of the underlying mechanisms.

We welcome the submission of Original Research papers, as well as Review, Research Report or specific comment on recently published articles that are related to this topic.