About this Research Topic
The prevalence of chronic metabolic diseases is continuously growing in industrialized countries. Cardiovascular, renal, pulmonary diseases along with diabetes, neurodegenerative disease and other conditions of chronic morbidity, especially in the elderly, today represent significant challenges for the search for new drugs and therapeutic targets in an attempt to contain the economic and social impact of these illnesses. Chronic inflammatory processes prompt the initiation and perpetuation of metabolic issues such as latent or florid inflammatory conditions that occur at the level of the intestinal mucosa with significant involvement of the Enteric Nervous System (SNE). Intestinal mucosa damage, and enteric neuroinflammatory immune priming, are therefore key events in the etiopathogenesis of gut-mediated neuropathological pathways in the development of different metabolic conditions in the brain, cardiac, lung, and kidney (gut-brain, gut-heart, gut-lung, and gut -kidney axis, respectively).
Failure of intestinal homeostasis is a key factor in the pathogenesis and progression of systemic inflammation, which can culminate in multiple organ failure and fatality. Despite the recognition of the importance of inflammatory dysregulation in chronic illnesses, the mechanisms underlying the role of intestinal inflammation in these disorders are not fully understood. The goal of this Research Topic is to provide a forum to advance research on the contribution of intestinal inflammation to the genesis and development of chronic diseases as well as to explore innovative gut-oriented pharmacological interventions in the attempt to achieve a beneficial impact on chronic disease course. Also, the topic welcomes clinical studies focused on the investigation of the possible correlation(s) existing among gut-inflammation, chronic disease course, and intestinal markers as predictive tools useful for early diagnosis of metabolic inflammation.
Manuscripts including Original Research papers, Reviews and Perspectives to be included in the present Research Topic should aim to:
• Improve understanding of the mechanisms, novel molecular and cellular pathways that link intestinal inflammation with chronic disease
• Identify gut mucosal inflammation markers as possible predictive tools for early diagnosis, and evolution of chronic diseases
• Clinical studies correlating gut-associated inflammation and chronic disease course
• Explore the pharmacological role of products in preventing/treating intestinal inflammation and thus chronic disease
Failure of intestinal homeostasis is a key factor in the pathogenesis and progression of systemic inflammation, which can culminate in multiple organ failure and fatality. Despite the recognition of the importance of inflammatory dysregulation in chronic illnesses, the mechanisms underlying the role of intestinal inflammation in these disorders are not fully understood. The goal of this Research Topic is to provide a forum to advance research on the contribution of intestinal inflammation to the genesis and development of chronic diseases as well as to explore innovative gut-oriented pharmacological interventions in the attempt to achieve a beneficial impact on chronic disease course. Also, the topic welcomes clinical studies focused on the investigation of the possible correlation(s) existing among gut-inflammation, chronic disease course, and intestinal markers as predictive tools useful for early diagnosis of metabolic inflammation.
Manuscripts including Original Research papers, Reviews and Perspectives to be included in the present Research Topic should aim to:
• Improve understanding of the mechanisms, novel molecular and cellular pathways that link intestinal inflammation with chronic disease
• Identify gut mucosal inflammation markers as possible predictive tools for early diagnosis, and evolution of chronic diseases
• Clinical studies correlating gut-associated inflammation and chronic disease course
• Explore the pharmacological role of products in preventing/treating intestinal inflammation and thus chronic disease
Keywords: ENTERIC INFLAMMATION, CHRONIC DISEASE, INTESTINAL HOMEOSTASIS, INFLAMMATORY MARKERS, METABOLIC NFLAMMATION
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
