About this Research Topic
Calcific Aortic Valve Disease is the most predominant form of valve pathology affecting more than 25% of the population. The majority of cases are thought to be acquired in the aging population, but the pathology is advanced in younger patients of congenital malformations include bicuspid aortic valve. Despite the prevalence, outcomes from pharmacological initiatives to treat risk factors remain unsubstantiated, and surgical procedures to repair or replace calcified valves come with insuperable complications regarding health, financial burden and no guarantee of long-term success. Therefore, the field continues to explore better alternatives. However, to date none have been found and this is likely due to the complex, multi-factorial nature of this disease and the difficulty in targeting multiple contributing factors.
In this research topic, we welcome review, methods and original article contributions that advance our understanding of calcific aortic valve disease etiology with a focus on genetics, developmental origins, signaling pathways, hemodynamic influences, novel model systems and therapeutic solutions.
The specific themes we would like contributors to address include, but are not limited to:
1) Genetics of Calcific Aortic Valve Disease.
2) Developmental origins of Calcific Aortic Valve Disease.
3) Hemodynamics influences on Calcific Aortic Valve Disease pathogenesis.
4) Novel model systems to study Calcific Aortic Valve Disease.
5) Signaling pathways that contribute to Calcific Aortic Valve Disease.
6) Therapeutic Solutions in the treatment of Calcific Aortic Valve Disease.
In this research topic, we welcome review, methods and original article contributions that advance our understanding of calcific aortic valve disease etiology with a focus on genetics, developmental origins, signaling pathways, hemodynamic influences, novel model systems and therapeutic solutions.
The specific themes we would like contributors to address include, but are not limited to:
1) Genetics of Calcific Aortic Valve Disease.
2) Developmental origins of Calcific Aortic Valve Disease.
3) Hemodynamics influences on Calcific Aortic Valve Disease pathogenesis.
4) Novel model systems to study Calcific Aortic Valve Disease.
5) Signaling pathways that contribute to Calcific Aortic Valve Disease.
6) Therapeutic Solutions in the treatment of Calcific Aortic Valve Disease.
Keywords: Heart Valve, Calcification, Hemodynamics, Endothelial Cells, Extracellular Matrix
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
