About this Research Topic
The anatomy of the eye, however, also makes pharmacological treatment challenging. The epithelium that lines the ocular surface is impermeable to most drugs or molecules. Although systemic absorption of ophthalmic agents can occur, it is minimal as the eye is normally isolated from systemic vascular. Hence, there is an increasing demand for a more effective and, ideally, non-invasive delivery methods for therapeutic agents to overcome the bioavailability issue. Also, the research of pharmacokinetics of existing drugs and drug toxicity is important in improving the effectiveness of the therapy as the knowledge of ocular pharmacology evolved.
This Special Issue attempts to highlight the current state and future perspectives in the evolving therapeutics in the anterior segment of the eye. The topic of focus in the issue can be one or the combination of two or more of the following:
• Advanced therapeutic products, such as stem cell, gene, and exosome therapies.
• Innovative drug cell delivery system in the form of nano or microparticles, drug-eluting contact lens, microneedles, hydrogel implants, or injectable implants.
• Drug pharmacokinetics.
• Drug toxicology.
• Drug discovery.
• Anti-infective therapeutic agents, which include anti-infective peptides, biomaterials, or coatings.
• Molecular simulation to analyze drug-tissue or drug-microorganism interactions.
Dr. Masaaki Kageyama is partly employed by Santen Pharmaceutical. All other Topic Editors declare no competing interests with regards to the Research Topic subject
Keywords: drug delivery, therapeutics, biomaterials, cataracts, cornea
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