About this Research Topic
The importance of post-traumatic and/or post-surgical inflammation for detrimental outcomes is beyond any doubt. Since numerous experimental triggers of specific immune responses and inflammation have been identified in pre-clinical experiments, and both detrimental but also regenerative roles have been described in these settings. It remains difficult however to assess their "friend or foe" function in the clinical post-traumatic immunogenicity and healing processes. Yet, next to their unknown pathomechanistic influence on the post-injury outcomes, several of those in vivo and in vitro elaborated mediators not only showed promising properties to be used as biomarkers to indicate and/or monitor disease or injury severity, but may also serve as clinically applicable parameters for optimized indication of the timing for i.e. secondary surgeries. The complexity of post-traumatic immunologic responses as well as unrevealed interactions among the different players in post-traumatic immune reactions require scientific intercommunication to share and connect new findings.
Accordingly, the aim of this Research Topic is to provide present the newest scientific insights on immunological and cellular reactions but also tissue related as well as circulatory responses after severe trauma or during further clinical course of critically ill patients. Here, we would like to invite authors to submit experimental and clinical studies, meta-analysis or reviews that focus on immunological reactions after severe trauma and in critically ill patients during their further clinical course. This includes but is not limited to studies investigating the relevance of biomarkers (e.g., cytokines, extracellular vesicles) as new diagnostic tools but also to monitor clinical progress as well as innovative treatment options focusing on the modification of the immunological response. Furthermore, clinical studies that concentrate on the presentation of new prevention strategies or investigate trauma/critically ill related factors affecting long-term outcome are of major interest.
Accordingly, the aim of this Research Topic is to provide present the newest scientific insights on immunological and cellular reactions but also tissue related as well as circulatory responses after severe trauma or during further clinical course of critically ill patients. Here, we would like to invite authors to submit experimental and clinical studies, meta-analysis or reviews that focus on immunological reactions after severe trauma and in critically ill patients during their further clinical course. This includes but is not limited to studies investigating the relevance of biomarkers (e.g., cytokines, extracellular vesicles) as new diagnostic tools but also to monitor clinical progress as well as innovative treatment options focusing on the modification of the immunological response. Furthermore, clinical studies that concentrate on the presentation of new prevention strategies or investigate trauma/critically ill related factors affecting long-term outcome are of major interest.
Keywords: Trauma, Critical Illness, Inflammation, Immune Response, Translational
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