About this Research Topic
Over the last several decades, hydrogen sulfide (H2S) has been reported to exert multiple physiological functions in mammal systems. Mounting evidence indicates the physiological significance of H2S because of its role in a wide range of physiological and pathological activities in mammal systems, especially in the cardiovascular system, central nervous system, and other biological systems. As such, H2S has gained recognition as the third gaseous signaling molecule along with nitric oxide (NO) and carbon monoxide (CO). Endogenous H2S in mammal systems is mainly generated by either enzymatic or non-enzymatic pathways. The enzymatic process is dependent on the actions of cystathione β-synthase (CBS), cystathione γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST). Our previous Research Topic, Hydrogen sulfide: Physiology, Pharmacology and Toxicology (Volume 1) launched in 2016, has been a highlight for the readership of the journal Frontiers in Pharmacology and has gained attention in the field. However, many aspects of H2S are still not yet fully understood and often controversial. As this is a recent and rapidly evolving field, an overview of the obtained results and the future perspectives is highly desirable. The complicated biological effects, long term toxic accumulation and lack of system specific effects continuously challenges scientists to develop H2S-releasing drugs.
The aim of the Volume 2 of this Research Topic is to highlight recent advances in our understanding of the physiological and pharmacological functions of H2S. We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the biogenesis, metabolism and biological functions of H2S. Submission of pharmacological functions/toxic effects and other related sulfide containing compounds are also welcome. Potential topics include, but are not limited to:
•Biological function in the new compounds releasing H2S, polysulfide and SO2
•New methods for detection of endogenous and exogenous H2S
•Advances in biosynthesis and metabolism of H2S.
•Current understanding about protein sulfhydration
•Signaling mechanisms underlying the biological functions of H2S
•Prospect of sulfide-containing nature products and H2S synthesis inhibitors as therapeutic drugs
The aim of the Volume 2 of this Research Topic is to highlight recent advances in our understanding of the physiological and pharmacological functions of H2S. We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the biogenesis, metabolism and biological functions of H2S. Submission of pharmacological functions/toxic effects and other related sulfide containing compounds are also welcome. Potential topics include, but are not limited to:
•Biological function in the new compounds releasing H2S, polysulfide and SO2
•New methods for detection of endogenous and exogenous H2S
•Advances in biosynthesis and metabolism of H2S.
•Current understanding about protein sulfhydration
•Signaling mechanisms underlying the biological functions of H2S
•Prospect of sulfide-containing nature products and H2S synthesis inhibitors as therapeutic drugs
Keywords: Hydrogen Sulfide; gaseous transmitter; sulfur dioxide; polysulfide; sulfhydration
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
