About this Research Topic
Oral administration has been considered as the most convenient approach for drug delivery due to its numerous advantageous features. For example, it avoids the pain and discomfort caused by the intravenous injection, intraperitoneal injection, and intrarectal injection, enables patients to easily self-medicate, and reduces the possibility of contamination. For a translational implementation of oral nanotherapeutics, numerous issues have to be addressed in the future, including: (1) the in vivo safety of nanotherapeutics after oral administration; (2) the in vivo stability of nanotherapeutics during transit in the gastrointestinal tract; (3) the drug retention amount and drug residence time, which have to be further optimized; and (4) simplification of nanotherapeutics, which will facilitate large-scale manufacturing. This Research Topic aims to highlight the advanced studies and strategies which might overcome current obstacles in the treatment of colon diseases.
This Research Topic welcomes Original Research, Review and Mini Review papers on, but not limited to, the following topic areas:
• Small therapeutic molecules against colon diseases
• Drug delivery materials and colon diseases
• Targeting ligands for drug delivery to colon tissues
• Plant-derived nanovehicles and colon diseases
• Diagnosis methods for colon diseases
• Intestinal microbiota and colon diseases
Important Note: All submissions/contributions to this Research Topic must be in line with the scope of the journal/section they are submitted to. While authors are encouraged to draw from other disciplines to enrich their papers where relevant, they must ensure papers fall within the scope of the journal/section, as expressed in its mission statement.
Dr. Bo Xiao and Dr. Didier Merlin hold several patents (approved and pending) including those on the topics of drug-loaded nanoparticles, and bowel disease and colon cancer treatment. Dr. Zeyu Xiao also holds patents, with one on 'Orally colon-targeted drug delivery systems'. All other Topic Editors declare no competing interests with regard to the Research Topic subject.
Keywords: Oral Administration, Nanoparticles, Inflammatory Disease, Colorectal Cancer
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.