About this Research Topic
Bioactive compounds can be modified to increase their effectiveness by increasing absorption and bioavailability and reducing the undesired side effects. They are still the basis of some contemporary medicines for the prevention or treatment of CNS disorders. The advantages of CNS diseases pharmacotherapy with natural products and their bioactive compounds are numerous: reduced side effects; addressability of an ageing population; use in parallel with allopathic medicines; prevents and not only treats; slow and prolonged action, giving the possibility to restore and regenerate damaged structures; active substances in plants act synergistically; and the presence of immunomodulatory properties that target neuroinflammation and modulate the brain structure and behavior.
With this Research Topic, we want to draw attention to the impact of natural derivatives in CNS disorders, with emphasis on molecular and cellular mechanisms, single or multiple biological targets; the safety of use, and possible interactions. We welcome you to contribute to this collection with Review, Mini-review, Perspectives, General Commentaries, Protocols, and Original Research articles, focusing on the medicinal properties of natural bioactive compounds with a beneficial effect on neurodegenerative disorders.
This Research Topic will cover the following subtopics:
• Natural bioactive compounds and natural medicinal products for the prevention and pharmacotherapy of neurodegenerative disorders and associated comorbidities;
• Nutraceuticals containing phytochemicals with antiaging effect by increase neuroprotection and brain plasticity;
• Biological targets for natural products;
• New technologies used for the optimal pharmaceutical formulation of bioactive compounds from herbal medicines (e.g nanoformulation, exosomal/liposomal delivery);
• Biological activity and mechanism of action that is underlying the pharmacological activity;
• Multimodal approaches of age-related neurodegenerative disorders therapy and associated comorbidities.
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One can find more information about the Article Type guidelines in the Ethnopharmacology section here.
All the manuscripts submitted to this project will be peer-reviewed and need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here).
Keywords: herbal medicines, natural bioactive compounds, pharmacological activity, molecular mechanisms of action, signalling pathways, nanoformulations, dementia, neurodegeneration, neurodevelopment, animal models of disease
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.