New Strategies in the Treatment of Thyroid Carcinoma

Differentiated thyroid carcinoma has seen an uprising in incidence over the past 20 years. Some authors attribute this to new developments in diagnostic screening and efficient detection of lesions located in the thyroid gland, which allows the diagnosis of early stage carcinomas. Consequently, the possibility of treating these cases with endoscopic surgery has raised opening a new quality of life panorama to selected patients. On the other hand, advanced malignancies are presented more frequently to specialized oncology centers, and approached with different strategies which test previous approaches utilized in the past. The possibility in these sometimes unresectable cases of a nonsurgical upfront therapy and subsequent resection has opened a new avenue to targeted and radiation therapy.

The objective of this Research Topic is to provide a rational and individualized approach for the treatment of thyroid carcinoma in different stages (early, intermediate and advanced), and to present the expertise of different authors who will address the usual problems faced in oncology practice. This project also welcomes innovations and new and potential developments for the future.

This Research Topic calls for original research articles and reviews around the following topics:
A. Diagnosis
 -Analyses of described cytology categories regarding indeterminate and follicular aspirates.
 -Detection and resection of neck base and mediastinum recurrences with image (ultrasound) and needle marking Radiodine use.
B. Definition and boundaries of endoscopic thyroidectomy for early lesions. Prevention of morbidity. Neuromonitoring.
C. Decision making for central compartment treatment in differentiated thyroid cancer.
D. New targeted therapies, radiotherapy, and surgery in unresectable differentiated thyroid cancer
E. Cricotracheal and tracheal resection in locally advanced thyroid cancer.