About this Research Topic
Genomic profiling has revealed the heterogeneity of gastrointestinal tumors, and the combination of inter-patient heterogeneity and intra-tumor heterogeneity was identified as a determining factor of tumor development. Molecular heterogeneity at multiple levels including genomics, epigenomics, transcriptomics, and microenvironment features conferring each patient variation in the response to anti-cancer therapies should be considered. Due to the heterogeneity of gastrointestinal cancers associated with different clinical biometrics, the prognosis of each patient is different. Therefore, more novel and effective anti-cancer therapeutic algorithms should be discussed to selected subsets of gastrointestinal tumors.
This Research Topic aims to provide a comprehensive overview of recent advances in the association between tumor heterogeneity and related anti-cancer therapies for gastrointestinal cancer. We welcome the submission of Review and Original Research articles covering, but not limited to, the following topics:
• Novel molecular mechanism research on the association between heterogeneity and related anti-cancer therapies for gastrointestinal tumors including gastric, colorectal, liver, pancreas, bile duct, and esophageal tumors.
• Novel clinical research focus on anti-cancer strategies derived from tumor heterogeneity studies for gastrointestinal cancer
• Novel therapeutic targets derived from tumor heterogeneity studies for gastrointestinal cancer
• Novel special heterogeneity biomarker to predict the anti-cancer treatment response and prognosis of gastrointestinal cancer
This Research Topic aims to provide a comprehensive overview of recent advances in the association between tumor heterogeneity and related anti-cancer therapies for gastrointestinal cancer. We welcome the submission of Review and Original Research articles covering, but not limited to, the following topics:
• Novel molecular mechanism research on the association between heterogeneity and related anti-cancer therapies for gastrointestinal tumors including gastric, colorectal, liver, pancreas, bile duct, and esophageal tumors.
• Novel clinical research focus on anti-cancer strategies derived from tumor heterogeneity studies for gastrointestinal cancer
• Novel therapeutic targets derived from tumor heterogeneity studies for gastrointestinal cancer
• Novel special heterogeneity biomarker to predict the anti-cancer treatment response and prognosis of gastrointestinal cancer
Keywords: Gastrointestinal Cancer, Heterogeneity, Molecular Target, Anti-Cancer Strategies
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
