About this Research Topic
Although great progress has been made in our understanding of organelle-specific autophagy in the context of viral infections, several important questions remain. For example, how do viruses regulate selective autophagy, and which signaling pathways are involved? What are the key receptors that drive the induction of organelle-specific autophagy? Which type of selective autophagy is more important to viral pathogenesis for viruses that induce more than one type of selective autophagy? How significant is organelle-specific autophagy in viral pathogenesis? Answering these and many other questions may require the development of better tools/markers that are sensitive but specific to selective autophagy. The answers to these questions could broaden our understanding of the relationship between organelle-specific autophagy and viral pathogenesis, and aid in the design of novel therapeutic strategies against these viruses.
This issue aims to highlight the most recent findings on viral interplay with organelle-specific autophagy and will accept both Original Research papers and Reviews related to the topic. The goal is to better understand the role of organelle-specific autophagy in the pathogenesis of viral infections. The themes to be addressed include but are not limited to viral regulation of any of the well-characterized forms of organelle-specific autophagy such as:
• Mitophagy
• Lipophagy
• ER-phagy
• Less characterized forms such as ribophagy in the context of viral infections
Keywords: Selective autophagy, organelle-specific, innate immune response, viral pathogenesis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.