Physiology and Metabolism of Yeast

The budding yeast Saccharomyces cerevisiae is one of the best-studied eukaryotic model organisms, and has a long history in the production of fermented beverages, ethanol and other commodities. It has well-established protocols and methods to modify its genome content, conveys high tolerance to environmental changes, can form diploid cells for robust growth and increased adaptation, and exhibits beneficial post-translational modifications, making it one of the most desirable hosts in Synthetic Biology. In addition, given its high efficiency in homologous recombination, Saccharomyces cerevisiae has also become the most widely used hosts in the development of technologies in Synthetic Biology such as assembly of large DNA fragments, whole genome metabolic modeling and the targeting of genome re-design and synthesis.

The goal of this Research Topic is to evaluate our current understanding of yeast as a host for synthetic biology applications, the development new tools and methods to engineer yeast, and the use of yeast as a cell factory for high-value chemical production.
The scope of the Research Topic will focus on advances in synthetic biology using yeast as a model organism. Reviews and Original Research articles are welcomed. Content covering the following areas are welcome but are not limited to:
• Physiology and metabolism of engineered yeast chassis
• Metabolic engineering for chemicals, fuel and materials in yeast
• Genetic Circuit Design in yeast
• Novel genetic parts design and characterisation for yeast
• Emerging tools for yeast synthetic biology
• Genome design and synthesis of yeast