Tooth Bleaching

According to a number of studies, low and high-concentrations of hydrogen peroxide (HP) could modify the structure and enamel mineral composition. Changes in the inorganic content of the dental structure could lead to microhardness decrease and increase on enamel roughness. Besides, the ability of HP to break down and form unstable reactive oxygen species (ROS) that diffuse through enamel / dentin and reaches the pulp chamber, raises important questions about pulp integrity and safety of the procedure. Clinically, this effect is noted as tooth sensitivity and although it is reported to be transient, the long-term effect on pulp tissue is still in debate. In order to cease, decrease or reverse the possible side effects on dental structure or pulp cells, researchers have focused on possibilities to change the composition of bleaching agents, or application protocol, or have invested in technologies to reach the bleaching effect uniquely with the use of certain types of lights.

Based on the exposed, this Research Topic aims to display reports of in vitro and clinical trials of bleaching effects on dental structure and tooth sensitivity. It also aims to contribute in the understanding of novel bleaching protocols, technologies and strategies to decrease the side effects promoted by HP and elucidate its mechanism of action.

We seek original research articles, review, mini-reviews, perspectives and brief research reports that may include (but not limited to):
· Efficacy, tooth sensitivity of home-applied, in-office bleaching techniques or over-the counter products.
· Adverse effects of bleaching agents on morphology, enamel mineral content and the use of remineralizing agents or changes on bleaching protocols
· Cytotoxicity effects of bleaching agents and strategies to minimize pulp response.
· Efficacy and safety of experimental agents with innovative composition
· The use of light and novel bleaching techniques
· The effect of bleaching agents on reconstruction materials