About this Research Topic
Breast cancer is one of the most prevalent malignancies and a major cause of cancer-associated death in women around the world. Chemotherapy, as the major systemic treatment for breast cancer, can help control or even eliminate metastatic lesions in breast cancer patients. However, the emergence of chemoresistance often leads to treatment failure and metastasis of breast cancer.
Many studies have confirmed that breast cancer metastasis is closely related to chemoresistance, and both of these events are regulated by a variety of genetic, epigenetic, and environmental factors. In clinical practice, breast cancer with resistance to chemotherapy is significantly associated with a high potential of distant metastasis and poor prognosis. Chemoresistance and metastasization remain the leading causes of breast cancer-related death.
This Research Topic aims to uncover the still unclear underlying molecular mechanisms for chemoresistance and metastasis, as well as report the latest progress related to new biomarkers, therapeutic targets and development of new treatment strategies which will contribute to improved therapeutic efficacy and prognosis for breast cancer patients.
We welcome Original Research, Reviews, Perspective and Opinion articles, focusing on but not limited to:
- High-throughput analysis to discover chemoresistance and metastasis related molecules
- Investigating predictive biomarkers in clinical research
- Evaluating the clinical application value of specific therapeutic targets
- Development of novel treatment strategies, such as targeted therapy, immunotherapy*, and nanotherapy
- The construction and application of in vivo/in vitro research models in investigating the molecular mechanisms or evaluating drug susceptibility
- The association between non-coding RNAs and chemoresistance and metastasis of breast cancer
- The role of cancer stem cells in chemoresistance and metastasis of breast cancer
- The interaction between the tumor microenvironment and breast cancer cells in modulating chemoresistance and metastasis of breast cancer
*We recommend that papers on immunotherapy are submitted to the Research Topic “Immunotherapy as an Evolving Approach for the Treatment of Breast Cancer” at https://www.frontiersin.org/research-topics/13346 if the submission date is before 30th August 2020
Studies demonstrating the applicability of anticancer modalities must present a minimum of two well-authenticated cancer cell lines.
Many studies have confirmed that breast cancer metastasis is closely related to chemoresistance, and both of these events are regulated by a variety of genetic, epigenetic, and environmental factors. In clinical practice, breast cancer with resistance to chemotherapy is significantly associated with a high potential of distant metastasis and poor prognosis. Chemoresistance and metastasization remain the leading causes of breast cancer-related death.
This Research Topic aims to uncover the still unclear underlying molecular mechanisms for chemoresistance and metastasis, as well as report the latest progress related to new biomarkers, therapeutic targets and development of new treatment strategies which will contribute to improved therapeutic efficacy and prognosis for breast cancer patients.
We welcome Original Research, Reviews, Perspective and Opinion articles, focusing on but not limited to:
- High-throughput analysis to discover chemoresistance and metastasis related molecules
- Investigating predictive biomarkers in clinical research
- Evaluating the clinical application value of specific therapeutic targets
- Development of novel treatment strategies, such as targeted therapy, immunotherapy*, and nanotherapy
- The construction and application of in vivo/in vitro research models in investigating the molecular mechanisms or evaluating drug susceptibility
- The association between non-coding RNAs and chemoresistance and metastasis of breast cancer
- The role of cancer stem cells in chemoresistance and metastasis of breast cancer
- The interaction between the tumor microenvironment and breast cancer cells in modulating chemoresistance and metastasis of breast cancer
*We recommend that papers on immunotherapy are submitted to the Research Topic “Immunotherapy as an Evolving Approach for the Treatment of Breast Cancer” at https://www.frontiersin.org/research-topics/13346 if the submission date is before 30th August 2020
Studies demonstrating the applicability of anticancer modalities must present a minimum of two well-authenticated cancer cell lines.
Keywords: Breast Cancer, Chemoresistance, Metastasis, Molecular Mechanisms, Clinical Strategy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
