About this Research Topic
Effective and safe treatments for COVID-19 are urgently needed. A considerable amount of molecules has been employed to treat patients according to preliminary preclinical and clinical results. Most of the ongoing clinical trials have been designed to test well-known (or anyway already approved) drugs.
Drug repurposing allows to rapidly study treatments, at lower costs and with reduced risk of failure as the safety profile of the medicine is typically well-established. Developing new drugs is obviously a lengthy process, thus unfeasible to face the immediate global emergency. At present, well-known anti-infective molecules (cloroquine/hydroxychloroquine, anti-retroviral drugs, anti-influenza, antibacterial agents), anti-rheumatic/anti-cytokine release syndrome drugs, antithrombotic agents are under clinical development for COVID-19.
The aim of this Research Topic is to explore the role of repurposed drugs with different mechanism of action (e.g. anti-viral, immunosuppressive/anti-inflammatory activity, pleiotropic activity) for COVID-19 and to reflect on regulatory challenges for drug repurposing in the pandemic era.
Keywords: COVID-19, repurposed drugs, anti-viral, anti-inflammatory, pleiotropic activity, drug repurposing
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