About this Research Topic
According to the World Health Organization, cardiovascular diseases are the major cause of chronic deaths worldwide. Multiple factors such as gender, physical inactivity, genetic, disturbances to the microbiome, and environmental factors such as stress, alcohol consumption, unhealthy diet, air pollution, and contaminants can trigger or modulate cardiovascular disorders. All these factors can direct or indirectly induce vascular dysfunction, thereby contributing to the progression of cardiovascular diseases and, consequently, leading to end-organ target complications.
Several approaches have been traditionally used to prevent or reverse vascular dysfunction associated to cardiovascular diseases. In addition to pharmacological therapy, alterations in eating habits and lifestyle are undoubtedly the most important non-pharmacological interventions in the prevention and treatment of cardiovascular diseases. Enhanced understanding of pathophysiological mechanisms and the pharmacological and non-pharmacological therapies (dietary approaches and physical training) could identify potential targets to prevent or minimize the vascular dysfunction in cardiovascular diseases.
This Research Topic aims to strengthen the understanding of the local vascular adjustments involved in cardiometabolic diseases. For this, we are interested in original and review papers that highlight the functional and molecular mechanisms of local pathophysiological adjustments involved in changes in vascular tonus, inflammation and remodeling, as well as the therapies for these alterations in cardiometabolic diseases.
Keywords: Cardiovascular disease, vascular tone, vascular remodeling, vascular inflammation
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