About this Research Topic
What is the explanation for these differences? Resilience may be one of the answers. In Psychology, resilience is defined as the process of adapting well in the face of adversity, trauma, threats or significant sources of stress. At the cellular level, resilience is the ability of cells to adapt to different insults or stressful conditions, activating molecular pathways to restore the cellular balance. Impaired resilience may be one possible explanation for an increased vulnerability for some individuals to develop bipolar disorder, and for those who show worse prognoses. Which factors are likely to be crucial for resilience? How could these factors influence the risk of developing bipolar disorder and impact on its progression? Considering the biological and psychological points of view, how can we measure and improve them? How are different types of resilience parameters linked to bipolar disorder?
Several molecular pathways related to bipolar disorder pathophysiology have already been identified and may help with understanding the progressive biological and clinical changes associated with this illness. Understanding the relationship across complex hierarchies of such biological processes (from the genome and transcriptional regulation, protein, and cellular changes), environmental influence and finally the ultimate clinical phenotype, will be a crucial focus of research in this field and will help to clarify the pathophysiology of the disorder and provide novel insights into personalized medicine.
This Research Topic welcomes scientific contributions, including Original Research, Reviews, meta-analyses, Case Report, and theoretical reflections and Perspectives that focus on understanding how resilience interacts with genetic and environmental factors to impact on biological changes in the body and clinical outcomes in bipolar disorder.
We welcome clinical and pre-clinical studies (including basic research in humans and/or animals) focused on identifying resilience factors at different levels, from cellular to psychological resilience (biological, social, and environmental factors), elucidating how such factors interact with known risk factors in bipolar disorder and lead to biological changes (alterations in peripheral and central biomarkers, imaging, genetics, epigenetics, molecular pathways) and clinical outcomes (functional/cognitive impairments, illness progression, response to treatment).
Keywords: Bipolar Disorder, Resilience, Genetic Risk Factor, Epigenetics, Environmental Risk Factor
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