About this Research Topic
The purpose of this Research Topic is to introduce recent advances in the study of skeletal regeneration and repair. Articles of interest include, but are not limited to, reports of research strategies, approaches, tools and applications related to extracellular vesicles, engineered matrices and epigenetic regulation, which can be leveraged to promote skeletal repair and regeneration. Both Original Research and Review articles are welcome on the following topics:
• Application of mesenchymal stromal/stem cells as biological agents that can produce extracellular vesicles, matrices and other paracrine factors required for promoting lineage-commitment of endogenous skeletal progenitors and attenuating inflammatory responses.
• Bioengineered extracellular vesicles as delivery vehicles for therapeutic drugs and molecules in skeletal tissue repair.
• Identification of molecular mechanisms and targets of mesenchymal stem/progenitor cells involved in the pathogenesis of skeletal degeneration such as aging, critical to the understanding of tissue repair.
• Investigation of pharmacological agents for epigenetic modification with established safety pro-files for short-term local therapies for skeletal tissue repair.
• Reprogram mesenchymal stromal/stem cells for large bone and cartilage defect repair
• Stem cell-friendly scaffold materials for bone and cartilage repair.
We would like to acknowledge Yixuan Pei as the Research Topic Co-ordinator, and thank them for their support on the collection's Editorial article.
Drs. Tong-Chuan He and Wan-Ju Li hold patents related to tissue and cartilage engineering. All other Topic Editors declare no competing interests with regard to the Research Topic subject.
Keywords: Mesenchymal Stem Cell, Cartilage Regeneration, Bone Regeneration, Extracellular Vesicle, Extracellular Matrix
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