About this Research Topic
A deep knowledge of the multiple interactions between biofilms and the immune system is critical to adequately address biofilm infections. The present Research Topic aims to gather a collection of papers addressing the immune response to bacterial/fungal biofilms. Special interest will be devoted to studies elucidating basic immune pathways possibly contributing to a protective immune response to biofilms, but also to the sophisticated mechanisms exploited by biofilm cells to evade such response. Biofilm-forming microorganisms are structurally and metabolically different as compared to their planktonic counterpart. Typically, they are embedded in a complex mixture of extracellular polymeric substances (EPS) they themselves produce that includes polysaccharides, proteins, lipid and extracellular DNA. Recent research has elucidated that EPS components may represent a source of biofilm specific antigens able to exert immunemodulating properties. The composition of EPS may greatly differ between a microbial species and even between strains within the same species, thus adding complexity to the elucidation of host immune responses to biofilm constituents. Identification of biofilm-specific antigens “seen” by host immune cells, as well as quantitative measurements of the host responses to biofilms, may help in identifying new anti-biofilm immunotherapeutic strategies as well as biomarkers of biofilm-associated infections.
The scope of this Research Topic is to provide a comprehensive overview of the actual knowledge of the host immune response to microbial biofilms. We seek Original Research, Review, Mini-Review, Hypothesis and Theory, Perspective, Clinical Trial and Case Report articles that cover, but are not limited to, the following topics:
• The role of innate immunity in host response to microbial biofilms
• The role of acquired immunity in host response to microbial biofilms • Identification of biofilm-specific ligand-receptor interactions during host defense
• In vitro and in vivo models/techniques to study the immunity to biofilms
• Immunotherapeutic approaches against biofilms
• Host responses promoting biofilms
Keywords: biofilm, biofilm infections, innate immune response, acquired immune response
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.