Phosphonate Chemistry in Drug Design and Development

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ORIGINAL RESEARCH

Published on 02 Jun 2021

Highly Diastereoselective Construction of Carbon– Heteroatom Quaternary Stereogenic Centers in the Synthesis of Analogs of Bioactive Compounds: From Monofluorinated Epoxyalkylphosphonates to α-Fluoro-, β-, or γ-Amino Alcohol Derivatives of Alkylphosphonates

Magdalena Rapp
Klaudia Margas-Musielak
Patrycja Kaczmarek
Agnieszka Witkowska
Tomasz Cytlak
Tomasz Siodła
Henryk Koroniak

doi 10.3389/fchem.2021.613633

2,073 views
5 citations

EDITORIAL

Published on 30 Apr 2021

Editorial: Phosphonate Chemistry in Drug Design and Development

Petri A. Turhanen
Konstantinos D. Demadis
Pawel Kafarski

doi 10.3389/fchem.2021.695128

2,749 views
16 citations

ORIGINAL RESEARCH

Published on 12 Jan 2021

Selective Inhibition of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases by the Phosphonate Analogs of Their 2-Oxo Acid Substrates

Artem V. Artiukhov
Alexey V. Kazantsev
Nikolay V. Lukashev
Marco Bellinzoni
Victoria I. Bunik

doi 10.3389/fchem.2020.596187

3,520 views
12 citations

REVIEW

Published on 08 Jan 2021

Overview of Biologically Active Nucleoside Phosphonates

Elisabetta Groaz
Steven De Jonghe

doi 10.3389/fchem.2020.616863

7,452 views
41 citations

ORIGINAL RESEARCH

Published on 06 Jan 2021

Synthesis of the 6-Substituted Imidazo[1,2-a]Pyridine-3-yl-2- Phosphonopropionic Acids as Potential Inhibitors of Rab Geranylgeranyl Transferase

Damian Kusy
Aleksandra Marchwicka
Joanna Małolepsza
Katarzyna Justyna
Edyta Gendaszewska-Darmach
Katarzyna Magdalena Błażewska

doi 10.3389/fchem.2020.596162

2,733 views
4 citations

REVIEW

Published on 06 Jan 2021

Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective

Jaeok Park
Vishal R. Pandya
Sean J. Ezekiel
Albert M. Berghuis

doi 10.3389/fchem.2020.612728

9,488 views
31 citations

REVIEW

Published on 13 Nov 2020

H-Phosphonate Chemistry in the Synthesis of Electrically Neutral and Charged Antiviral and Anticancer Pronucleotides

Adam Kraszewski
Michal Sobkowski
Jacek Stawinski

doi 10.3389/fchem.2020.595738

7,517 views
13 citations

ORIGINAL RESEARCH

Published on 11 Nov 2020

(S)-Thienyl and (R)-Pirydyl phosphonate Derivatives Synthesized by Stereoselective Resolution of Their Racemic Mixtures With Rhodotorula mucilaginosa (DSM 70403) - Scaling Approaches

Katarzyna Lubiak-Kozłowska
Małgorzata Brzezińska-Rodak
Magdalena Klimek-Ochab
Tomasz K. Olszewski
Monika Serafin-Lewańczuk
Ewa Żymańczyk-Duda

doi 10.3389/fchem.2020.589720

1,710 views
5 citations

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Medicinal and Pharmaceutical Chemistry
Organic Chemistry

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Articles

Highly Diastereoselective Construction of Carbon– Heteroatom Quaternary Stereogenic Centers in the Synthesis of Analogs of Bioactive Compounds: From Monofluorinated Epoxyalkylphosphonates to α-Fluoro-, β-, or γ-Amino Alcohol Derivatives of Alkylphosphonates

Editorial: Phosphonate Chemistry in Drug Design and Development

Selective Inhibition of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases by the Phosphonate Analogs of Their 2-Oxo Acid Substrates

Overview of Biologically Active Nucleoside Phosphonates

Synthesis of the 6-Substituted Imidazo[1,2-a]Pyridine-3-yl-2- Phosphonopropionic Acids as Potential Inhibitors of Rab Geranylgeranyl Transferase

Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective

H-Phosphonate Chemistry in the Synthesis of Electrically Neutral and Charged Antiviral and Anticancer Pronucleotides

(S)-Thienyl and (R)-Pirydyl phosphonate Derivatives Synthesized by Stereoselective Resolution of Their Racemic Mixtures With Rhodotorula mucilaginosa (DSM 70403) - Scaling Approaches

Frontiers in Chemistry

Medicinal and Pharmaceutical Chemistry

Organic Chemistry