About this Research Topic
The goal of this Research Topic is to solicit input from researchers on both sides of this “scientific river” on specific areas and methodologies to study key clinical questions in animals and suggestions on how to validate important mechanistic preclinical findings in humans.
We welcome articles addressing the following subtopics and other challenges of investigating the consequences of childhood adversity in humans and animals.
• Modeling and quantifying abusive and erratic parental behavior in humans and animal studies.
• The effects of different types (e.g. neglect vs. threat) and timing of adversities on the development of circuits that regulate threat detection, stress reactivity, reward sensitivity, impulsivity, pain, and immune response.
• The mechanisms by which multiple adversities interact to increase the risk for a broad range of health-related outcomes in a dose-dependent manner.
• The utility of imaging techniques such as resting-state fMRI, diffusion MRI, positron emission tomography to study connectivity, myelination, and immune activation in animals and humans exposed to early adversity.
• The role that sex and Individual differences play in mediating vulnerability and resiliency to childhood adversity.
• The use of peripheral biomarkers to assess early adversity and their relationship to developmental and behavioral changes.
Keywords: Childhood adversity, early life stress, neurodevelopment, health, animal models, imaging, peripheral biomarkers
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.