About this Research Topic
The aim of this Research Topic is to provide a broad view on current analytical, methodological, and conceptual advances in Neuroproteomics to understand CNS drug treatment effects and disorders.
Neuroproteomics is at the forefront of improving our understanding of molecular mechanisms underlying both the pathology of neurological disorders and the effects of drug treatment. While advances in mass spectrometry (MS) instrumentation and analysis are providing vast possibilities such as quantitative evaluation of approaching 8,0000 proteins in a sample, challenges are provided by the inherent complexity of the central nervous system (CNS). This complexity lies not only in the cell-type diversity from neurons to glia, but also in the relevance of circuit communication to function and the often significant distances between the axon targets and cell body of a neuron that coordinate neuronal function.
This Research Topic will compile novel findings ranging from whole proteome analysis, brain region specific proteomics, post-translational modifications of receptors and other key synaptic proteins, protein-protein interactions and interactomes, and approaches and analysis used to provide greater resolution via neuronal cell type specific proteomes (interneurons, pyramidal neurons) and sub-cellular proteomes such as the synaptic proteome. In addition, bioinformatics approaches for analysis of big data sets, and the integration of RNA and protein level analysis will be presented. Neuroproteomics has vast potential to reveal complex and novel mechanisms contributing to neurological disorders, identify biomarkers for diagnosis and monitoring of disease, and improve our ability to deploy both existing therapeutics and future drug targets to ameliorate or resolve CNS disorders.
Our Research Topic welcomes Original Research articles, Reviews, Mini Review, Perspectives, Methods, Protocols, Technology Report, and General Commentary.
Neuroproteomics is at the forefront of improving our understanding of molecular mechanisms underlying both the pathology of neurological disorders and the effects of drug treatment. While advances in mass spectrometry (MS) instrumentation and analysis are providing vast possibilities such as quantitative evaluation of approaching 8,0000 proteins in a sample, challenges are provided by the inherent complexity of the central nervous system (CNS). This complexity lies not only in the cell-type diversity from neurons to glia, but also in the relevance of circuit communication to function and the often significant distances between the axon targets and cell body of a neuron that coordinate neuronal function.
This Research Topic will compile novel findings ranging from whole proteome analysis, brain region specific proteomics, post-translational modifications of receptors and other key synaptic proteins, protein-protein interactions and interactomes, and approaches and analysis used to provide greater resolution via neuronal cell type specific proteomes (interneurons, pyramidal neurons) and sub-cellular proteomes such as the synaptic proteome. In addition, bioinformatics approaches for analysis of big data sets, and the integration of RNA and protein level analysis will be presented. Neuroproteomics has vast potential to reveal complex and novel mechanisms contributing to neurological disorders, identify biomarkers for diagnosis and monitoring of disease, and improve our ability to deploy both existing therapeutics and future drug targets to ameliorate or resolve CNS disorders.
Our Research Topic welcomes Original Research articles, Reviews, Mini Review, Perspectives, Methods, Protocols, Technology Report, and General Commentary.
Keywords: drug treatment, quantitative proteomics, label-free quantitation, neurotransmission, neuroproteomics
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