Quo Vadis Lipid Mediators – Lipid Mediators Implication in Inflammation and Chronic Inflammatory Diseases

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Background

Lipids are involved in the induction, resolution, and chronicity of immune responses. Most of the effects described in inflammation and immune response are from metabolites derived from the fatty acids AA, DHA, and EPA. However, along with the improvement of new analytical methods and protocols, an enormous amount of new lipid structures, simple, complex, and modified, have been described, and little is known about their biological function. There is an increased need to validate them, understand their possible role in cell response, in physiological and pathological conditions, and particularly their role in inflammation and immune response. Additionally, the involved signaling pathways, the possible pharmacological use, and their receptor-dependent or independent effects must be elucidated.

The first goal of this Research Topic is to provide a comprehensive overview of several aspects related to methods of analysis and quantification of lipid structures (complex and modified) and their importance in the immune response. The second goal is to summarize current knowledge on variations of levels of lipid metabolites during the inflammatory reaction, which results from modulation of catabolism and anabolism of phospholipids, saturated and unsaturated fatty acids, sphingolipids and glycolipids. The third goal is to summarize the results which link the aberrant lipid metabolism with chronic inflammatory diseases to better understand the importance of lipid mediators in the resolution of inflammatory responses and aging and to explore novel therapeutic interventions aimed at modulating lipid mediators to benefit affected patients. Accordingly, the following Research Topic will be devoted to 1) the detection and quantification of different lipid mediators and metabolites as well as their receptors along with controversies on the quantification of different lipid mediators and emerging new lipidomics mediators; 2) Extensive discussion regarding the generation of lipid mediators, and the importance of enzymes regulating their synthesis and catabolism, post-transcriptional modification of enzymes and isoenzymes, and their tissue distribution. 3) Importance of lipid mediators in specific inflammatory diseases and aging.

The topics that we would like to address are:

• Pro-resolving lipid mediators.
• Lipid metabolites in acute and chronic inflammation.
• Hydroxylated lipids and their possible role in diseases.
• Modified lipids and their role in the immune response.
• Lipid receptors and their importance in the immune response.
• Transcription factors and miRNA involved in the regulation of fatty acid and lipid mediators biosynthesis.
• Enzymes involved in lipid mediator biosynthesis and the importance of posttranscriptional modifications in the regulation of their activities.
• Pharmacological modulation of lipid metabolites and their receptors.
• Lipid mediators in allergic asthma and cystic fibrosis.
• Importance of lipid mediators in cancer progression and metastatic disease.
• Role of lipids mediators in aging.

We welcome the submission of all types of manuscripts which focus on critical aspects of lipid metabolism (anabolism and catabolism), immune response, and new aspects on the analysis of mediators, the role of these metabolites in disease progression and resolution, and the pharmacological implications of the mediators and their receptors.

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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