About this Research Topic
Much data supports the premise that the PGs influence cell behavior via GAGs in processes mediated by the microenvironment. A critical question in PG/GAG biology is how we can target specific GAG structures and PGs to unravel phenotypic and functional outcomes, as well as develop exploitation routes for understanding and regulating multiple cellular functions. Specifically, which PGs are critical in these processes, at which stage of proliferation/differentiation, in what context/tissue/function and how are they in turn regulated is yet to be elucidated, yet has profound implications and diverse applications. Current strategies to unravel these complex interactions include stem cell and regenerative models, human vs. other models, biomaterials, and biochemical approaches.
This Research Topic aims to provide evidence of current studies aimed at understanding key PGs and the tools used to identify and exploit their role in mediating cell behaviors. Thus, the aim of this Research Topic is to collect original research articles, short communications, reviews, mini-reviews, methods/protocols, and perspectives that contribute to the advancements our understanding of PGs.
The following areas can be covered in the scope of this Research Topic:
• Stem cells and regenerative models
• Biomaterials and PG interactions
• Biochemical approaches to PG biology
• PG regulation of signaling molecules
• PGs in exosome biology
• GAG production methods
• Glycocalyx and human health
• PGs in vitro and in vivo
• PGs and tissue homeostasis
• PGs and oncology
• PG technologies in health and disease
• Glycan therapeutics
• PGs as drugs
Keywords: Proteoglycans, Glycocalyx, Glycosaminoglycans, Therapeutics, Cell Behavior
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.