About this Research Topic
Hypoxia-ischemia is an important cause of brain injury in the perinatal period that can result in neonatal encephalopathy. When neonatal encephalopathy occurs, it frequently leads to serious neurological sequelae in newborns, with devastating consequences for families and society, contributing to over 50 million disability-adjusted life years worldwide each year.
Experimental evidence has proven the potential of hypoxia-ischemia for triggering a series of deleterious cascades that often damage the whole brain. These pathological mechanisms include acute energy failure, excitotoxicity, mitochondrial dysfunction, oxidative stress and inflammation, among others. Since the beginning of this century, hypothermia has become the only clinical strategy able to reduce, at least in part, the adverse neurodevelopmental outcome of asphyctic newborns. However, its therapeutic effect is limited, and around 40% of infants suffering from neonatal encephalopathy do not show benefit after cooling.
The purpose of this Research Topic is to publish high quality basic, translational and clinical original research and review articles that might contribute to a better understanding of neonatal brain injury. Potential themes include, but are not limited to:
• Perinatal hypoxia-ischemia, preterm birth and neonatal stroke
• Novel cellular and molecular mechanisms and potential targets for interventions
• Therapeutic hypothermia and combination therapy
• Biomarkers in the fetus and newborn
• Antioxidant molecules
• Novel interventions with a potential to induce neuroprotection
• Modulation of the neuroregenerative capacity of the brain
Experimental evidence has proven the potential of hypoxia-ischemia for triggering a series of deleterious cascades that often damage the whole brain. These pathological mechanisms include acute energy failure, excitotoxicity, mitochondrial dysfunction, oxidative stress and inflammation, among others. Since the beginning of this century, hypothermia has become the only clinical strategy able to reduce, at least in part, the adverse neurodevelopmental outcome of asphyctic newborns. However, its therapeutic effect is limited, and around 40% of infants suffering from neonatal encephalopathy do not show benefit after cooling.
The purpose of this Research Topic is to publish high quality basic, translational and clinical original research and review articles that might contribute to a better understanding of neonatal brain injury. Potential themes include, but are not limited to:
• Perinatal hypoxia-ischemia, preterm birth and neonatal stroke
• Novel cellular and molecular mechanisms and potential targets for interventions
• Therapeutic hypothermia and combination therapy
• Biomarkers in the fetus and newborn
• Antioxidant molecules
• Novel interventions with a potential to induce neuroprotection
• Modulation of the neuroregenerative capacity of the brain
Keywords: neonatal, brain, neuroprotection, neurorepair, therapies
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