About this Research Topic
However, the study of how both natural and artificial ligands influence the behaviour of receptors can be challenging and often requires multidisciplinary strategies. Ligands can be promiscuous in their binding, and different ligand-receptor interactions trigger a plethora of outcomes, which depend on the cellular context.
Emerging integrative approaches to assess ligand-receptor interactions include:
i) biochemical methods revealing receptor post-translational modifications, interactors and second messengers production.
ii) computational analyses estimating the contribution of lipid bilayers.
iii) biophysical methods to measure membrane receptor dynamics and
oligomerization state upon ligand binding.
iv) -omics approaches aiming to study ligand-induced modulation of gene or protein expression.
This Research Topic aims to offer a comprehensive view of multidisciplinary strategies used to study ligand-receptor systems in different physio-pathological contexts. This would provide biologists with a set of guidelines to promote the translation of such approaches to study any ligand-receptor system.
We welcome Original Research papers, Methods, Review and Mini-Review, Data Report, Perspective and Brief Research Report.
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