Genetic, Epigenetic, and Epitranscriptomic Mechanisms Associated with Learning and Memory

Learning and memory are key brain functions required for the acquisition, storage and retrieval of novel knowledge. To date, large collections of genes have been associated with learning and memory processes. Specifically, recent studies on neuronal activation, driven by learning and memory paradigms, have revealed that both epigenetic modifications on these genes and epitranscriptomic modifications on their messenger RNAs are essential for the assembly and maintenance of neural circuits. However, such molecular mechanisms remain largely unexplored and little is known of the epigenetic and epitranscriptomic control/maintenance/regulation of our thoughts, feelings and behaviours.

This Research Topic is particularly interested in the understanding of genetic, epigenetic, and epitranscriptomic regulatory mechanisms of neuronal plasticity. Upon neuronal activation, external stimuli initiate signal transduction cascades to regulate gene expression via epigenetic/epitranscriptomic modifications. Molecular aberrations in these regulatory pathways contribute to various kinds of learning disability and memory deficits. The identification of genetic mutations and epigenetic abnormalities in writers, erasers and readers of epigenetic/epitranscriptomic marks will improve our understanding of neurological diseases and complications, including autism, schizophrenia, addiction, and Alzheimer’s diseases. We appreciate studies using combinatory technologies including genetic/epigenetic manipulation, cellular and molecular analyses of neuronal systems and behavioural test batteries.