About this Research Topic
Mechanistic studies show adipose tissue affects adjacent tumor tissue progression via paracrine adipokine, inflammatory cytokine, angiogenic cytokine, metabolites, or extracellular matrix compositions. Nevertheless, it modulates distant tumor tissue via endocrine signaling or regulation of global inflammatory status. Thus, pharmacological or physiological interventions targeting these pathways may delay the onset and progression of cancer, reduce the metastasis, or reverse drug resistance. Moreover, BMI itself has its limitations as a measurement of adiposity and, thus, is not an ideal marker for identifying high-risk individuals. Instead, understanding the detailed mechanism of cross-talk between various adipose cellular components is vital for discovering new therapies, finding potential drug targets, and identifying new biomarkers for more personalized interventions.
In this research topic, we would like to welcome microenvironmental studies with clear molecular mechanisms, new concept of organ communications, or direct clinical relevance. We welcome mechanistic microenvironmental studies or comprehensive reviews focusing on:
• The molecular mechanism of the interaction between various cellular components in the adipose tissue microenvironment in cancer.
• Adipose tissue inflammation and its consequences for the onset and progression of cancer.
• Biomarker identification for metabolic syndromes.
• Targeting molecular pathways of adipose tissue microenvironment for cancer treatment.
Keywords: Adipose Tissue Microenvironment, Metabolic Syndrome, Tumor Microenvironment, Fat Metabolism, Cancer Therapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.