About this Research Topic
In this special collection of articles, we focus on natural products and natural product mimics and their derivatives that play modulatory or inhibitory roles in the epigenome. While current reviews mostly lay emphasis on naturally occurring epigenetic inhibitors and modulators of human disease targets, this series also looks at the epigenome of microbes and plants, which host the biosynthesis processes for making secondary metabolites.
Submissions (Editorials, Reviews, Concepts, Notes, Perspectives, Original Research, Book Reviews, etc.) are welcome in (but not limited to) the following topics:
• Natural remedies and pharmacogenomics of age-related and neurodegenerative disorders
• Implications of compounds of natural origin in disease-associated epigenetic mechanisms.
• Chemoinformatics exploration of the chemical space and target space of natural products with epigenetic functions.
• Bromodomain inhibitors of natural origin.
• A (re)classification of sirtuins and histone deacetylases based on current knowledge.
• Epigenetics in plant and marine life forms, fungal and microbial biosynthesis.
• Epigenetics and network pharmacology associated with treatment with natural remedies.
• Protein glycosylation and implications for genes, environment and disease.
• Repurposing of natural products with epigenetic functions through an integrated –omics analysis
Keywords: Epigenetics, Drugs, Inhibition, Chromatin, Methylation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.